EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
3.4.21.76 | cytochalasin B | PR3 and CD177 are increased in parallel. Stimulating cells with cytochalasin B in combination with fML, PmPR3- and CD177-negative cells become positive | Homo sapiens | |
3.4.21.76 | fMLP | PR3 and CD177 are increased in parallel. Causes a moderate increase. stimulating cells with cytochalasin B in combination with fML, PmPR3- and CD177-negative cells become positive | Homo sapiens | |
3.4.21.76 | PMA | PR3 and CD177 are increased in parallel. Increases 4.9fold. mPR3- and CD177-negative cells become positive | Homo sapiens | |
3.4.21.76 | TNF-alpha | PR3 and CD177 are increased in parallel. Causes a moderate increase | Homo sapiens |
EC Number | Application | Comment | Organism |
---|---|---|---|
3.4.21.76 | medicine | PR3- and CD177-expressing neutrophils constitute a subpopulation of neutrophils with an unknown role in the innate immune system, which may play an important role in diseases such as Wegeners granulomatosis and polycythemia vera | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.4.21.76 | cell surface | strong correlation between PR3 and CD177 surface expression | Homo sapiens | 9986 | - |
3.4.21.76 | plasma membrane | PR3 and CD177 exhibit a dynamic plasma membrane expression with rapid internalization and re-expression | Homo sapiens | 5886 | - |
3.4.21.76 | secondary granule | - |
Homo sapiens | - |
- |
3.4.21.76 | secretory vesicle | - |
Homo sapiens | 99503 | - |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.21.76 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.21.76 | neutrophil | PR3 and CD177 are coexpressed on a subset of neutrophils | Homo sapiens | - |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.21.76 | PR3 | - |
Homo sapiens |
3.4.21.76 | proteinase 3 | - |
Homo sapiens |