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Literature summary extracted from

  • Bauer, S.; Abdgawad, M.; Gunnarsson, L.; Segelmark, M.; Tapper, H.; Hellmark, T.
    Proteinase 3 and CD177 are expressed on the plasma membrane of the same subset of neutrophils (2007), J. Leukoc. Biol., 81, 458-464.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.76 cytochalasin B PR3 and CD177 are increased in parallel. Stimulating cells with cytochalasin B in combination with fML, PmPR3- and CD177-negative cells become positive Homo sapiens
3.4.21.76 fMLP PR3 and CD177 are increased in parallel. Causes a moderate increase. stimulating cells with cytochalasin B in combination with fML, PmPR3- and CD177-negative cells become positive Homo sapiens
3.4.21.76 PMA PR3 and CD177 are increased in parallel. Increases 4.9fold. mPR3- and CD177-negative cells become positive Homo sapiens
3.4.21.76 TNF-alpha PR3 and CD177 are increased in parallel. Causes a moderate increase Homo sapiens

Application

EC Number Application Comment Organism
3.4.21.76 medicine PR3- and CD177-expressing neutrophils constitute a subpopulation of neutrophils with an unknown role in the innate immune system, which may play an important role in diseases such as Wegener’s granulomatosis and polycythemia vera Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.76 cell surface strong correlation between PR3 and CD177 surface expression Homo sapiens 9986
-
3.4.21.76 plasma membrane PR3 and CD177 exhibit a dynamic plasma membrane expression with rapid internalization and re-expression Homo sapiens 5886
-
3.4.21.76 secondary granule
-
Homo sapiens
-
-
3.4.21.76 secretory vesicle
-
Homo sapiens 99503
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.76 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.76 neutrophil PR3 and CD177 are coexpressed on a subset of neutrophils Homo sapiens
-

Synonyms

EC Number Synonyms Comment Organism
3.4.21.76 PR3
-
Homo sapiens
3.4.21.76 proteinase 3
-
Homo sapiens