EC Number | Application | Comment | Organism |
---|---|---|---|
2.1.4.1 | medicine | creatine deficiency syndromes, either due to AGAT, GAMT or SLC6A8 deficiencies, lead to a complete absence, or a very strong decrease, of creatine within the brain | Mammalia |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.4.1 | L-arginine + glycine | Mammalia | - |
L-ornithine + guanidinoacetate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.1.1.2 | Homo sapiens | - |
- |
- |
2.1.1.2 | Mus musculus | - |
- |
- |
2.1.4.1 | Mammalia | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.1.1.2 | astrocyte | - |
Mus musculus | - |
2.1.1.2 | astrocyte | - |
Homo sapiens | - |
2.1.1.2 | brain | expressed within the brain, both during development and in adulthood | Mus musculus | - |
2.1.1.2 | brain | expressed within the brain, both during development and in adulthood | Homo sapiens | - |
2.1.1.2 | central nervous system | - |
Mus musculus | - |
2.1.1.2 | central nervous system | - |
Homo sapiens | - |
2.1.1.2 | cerebral gray matter | - |
Mus musculus | - |
2.1.1.2 | cerebral gray matter | - |
Homo sapiens | - |
2.1.1.2 | liver | - |
Mus musculus | - |
2.1.1.2 | liver | - |
Homo sapiens | - |
2.1.1.2 | additional information | not expressed in microcapillary endothelial cells | Mus musculus | - |
2.1.1.2 | additional information | not expressed in microcapillary endothelial cells | Homo sapiens | - |
2.1.1.2 | neuron | - |
Mus musculus | - |
2.1.1.2 | neuron | - |
Homo sapiens | - |
2.1.1.2 | oligodendrocyte | - |
Mus musculus | - |
2.1.1.2 | oligodendrocyte | - |
Homo sapiens | - |
2.1.4.1 | brain | - |
Mammalia | - |
2.1.4.1 | central nervous system | - |
Mammalia | - |
2.1.4.1 | kidney | - |
Mammalia | - |
2.1.4.1 | liver | - |
Mammalia | - |
2.1.4.1 | pancreas | - |
Mammalia | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.2 | S-adenosyl-L-methionine + guanidinoacetate | - |
Mus musculus | S-adenosyl-L-homocysteine + creatine | - |
? | |
2.1.1.2 | S-adenosyl-L-methionine + guanidinoacetate | - |
Homo sapiens | S-adenosyl-L-homocysteine + creatine | - |
? | |
2.1.4.1 | L-arginine + glycine | - |
Mammalia | L-ornithine + guanidinoacetate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.1.1.2 | GAMT | - |
Mus musculus |
2.1.1.2 | GAMT | - |
Homo sapiens |
2.1.1.2 | guanidinoacetate methyltransferase | - |
Mus musculus |
2.1.1.2 | guanidinoacetate methyltransferase | - |
Homo sapiens |
2.1.4.1 | AGAT | - |
Mammalia |
2.1.4.1 | arginine:glycine amidinotransferase | - |
Mammalia |
2.1.4.1 | glycine amidinotransferase | - |
Mammalia |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.1.1.2 | malfunction | GAMT-cerebrospinal fluid knockout mice show decreased levels of creatine within their brain, which however still reach 1.4 mM or 0.4-0.5 mol/g of tissue, and a very significant increase in guanidinoacetate (1.9 mol/g tissue), GAMT knockout mice slowly replenish their brain creatine upon creatine treatment | Mus musculus |
2.1.1.2 | malfunction | GAMT-deficient patients have strongly decreased levels of creatine in cerebrospinal fluid but are able to import creatine from the blood | Homo sapiens |