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Literature summary extracted from

  • Kihara, Y.; Yanagida, K.; Masago, K.; Kita, Y.; Hishikawa, D.; Shindou, H.; Ishii, S.; Shimizu, T.
    Platelet-activating factor production in the spinal cord of experimental allergic encephalomyelitis mice via the group IVA cytosolic phospholipase A2-Lyso-PAFAT axis (2008), J. Immunol., 181, 5008-5014.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.3.1.67 medicine metabolic role in inflammatory disorders using experimental allergic encephalomyelitis (EAE), an animal model for multiple sclerosis (MS) Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.67 acetyl-CoA + lyso-platelet-activating factor Mus musculus
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 platelet-activating factor + CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.67 Mus musculus
-
-
-
2.3.1.67 Mus musculus Q8BYI6 mouse; female mice, 8 weeks old, induced with experimental allergic encephalomyelitis (EAE), induction phase, acute phase, and chronic phase, C57BL/6 genetic background
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.67 central nervous system primary cultured cells of Mus musculus
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2.3.1.67 microglia mRNA and protein expressed in Mus musculus
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2.3.1.67 microglia mRNA transcript and protein are predominatly expressed in experimental allergic encephalomyelitis (EAE) mice Mus musculus
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2.3.1.67 spinal cord experimental allergic encephalomyelitis (EAE) mice, after 12d, 19d, and 34d removed Mus musculus
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2.3.1.67 spinal cord enzymatic activity and mRNA transcripts are elevated in experimental allergic encephalomyelitis (EAE) mice Mus musculus
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Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.67 additional information
-
 transcript level and enzyme activity elevated in spinal cord of experimental allergic encephalomyelitis (EAE) mice, correlation with disease severity, accumulation of platelet-activating factor dependent on the group IVA cytosolic PLA2/LysoPAFAT present in infiltrating macrophages and activated microglia Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.67 acetyl-CoA + lyso-platelet-activating factor
-
 Mus musculus platelet-activating factor + CoA
-
 ?
2.3.1.67 acetyl-CoA + lyso-platelet-activating factor metabolic processing of platelet-activating factor (PAF) in naive and experimental allergic encephalomyelitis (EAE) mice Mus musculus platelet-activating factor + CoA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.67 acetyl-CoA:lysoPAF acetyltransferase
-
 Mus musculus
2.3.1.67 lyso-PAF acetyltransferase
-
 Mus musculus
2.3.1.67 lysoPAFAT
-
 Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.67 37
-
 assay at Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.67 7.4
-
 assay at Mus musculus

General Information

EC Number General Information Comment Organism
2.3.1.67 physiological function activities of phospholipase A2 and acetyl-CoA:lyso-PAF acetyltransferase (LysoPAFAT) are elevated in the spinal cord of experimental allergic encephalomyelitis (EAE) mice, an animal model for multiple sclerosis, compared with those of naive mice and correlate with disease severity Mus musculus