EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
3.1.4.53 | isoproterenol | 0.001 mM isoproterenol triggers a sustained, 2fold increase in PDE4 activity | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.15 | 59-74E | - |
Homo sapiens | |
3.1.4.53 | rolipram | specific PDE4 inhibitor, complete inhibition at 0.01 mM rolipram | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.11.15 | additional information | - |
additional information | kinetics | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.11.15 | ATP + beta2-adrenergic receptor | Homo sapiens | role of GRK activity in the regulation of beta2 adrenergic signaling, feedback mechanism, overview | ADP + beta2-adrenergic receptor phosphate | - |
? | |
2.7.11.15 | additional information | Homo sapiens | GRK-mediated desensitization of beta2-adrenergic receptors is sufficient to cause declines in cAMP signals. GRK-mediated desensitization is primarily responsible for a sustained suppression of beta2AR signaling, overview | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.11.15 | Homo sapiens | - |
- |
- |
3.1.4.53 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.11.15 | HEK-293 cell | - |
Homo sapiens | - |
3.1.4.53 | HEK-293 cell | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.11.15 | ATP + beta2-adrenergic receptor | - |
Homo sapiens | ADP + beta2-adrenergic receptor phosphate | - |
? | |
2.7.11.15 | ATP + beta2-adrenergic receptor | role of GRK activity in the regulation of beta2 adrenergic signaling, feedback mechanism, overview | Homo sapiens | ADP + beta2-adrenergic receptor phosphate | - |
? | |
2.7.11.15 | additional information | GRK-mediated desensitization of beta2-adrenergic receptors is sufficient to cause declines in cAMP signals. GRK-mediated desensitization is primarily responsible for a sustained suppression of beta2AR signaling, overview | Homo sapiens | ? | - |
? | |
3.1.4.53 | 3',5'-cAMP + H2O | - |
Homo sapiens | 5'-AMP | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.1.4.53 | PDE4 | - |
Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.15 | ATP | - |
Homo sapiens |