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Literature summary extracted from

  • Klinghammer, M.; Tenhaken, R.
    Genome-wide analysis of the UDP-glucose dehydrogenase gene family in Arabidopsis, a key enzyme for matrix polysaccharides in cell walls (2007), J. Exp. Bot., 58, 3609-3621.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.22 expression of isoforms Ugd2, Ugd3, Ugd4 in Escherichia coli Arabidopsis thaliana

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.22 UDP-xylose
-
 Arabidopsis thaliana

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.22 0.042
-
 NAD+ isoform Ugd3, pH 8.7, 22°C Arabidopsis thaliana
1.1.1.22 0.043
-
 NAD+ isoform Ugd2, pH 8.7, 22°C Arabidopsis thaliana
1.1.1.22 0.044
-
 NAD+ isoform Ugd4, pH 8.7, 22°C Arabidopsis thaliana
1.1.1.22 0.123
-
 UDP-glucose isoform Ugd2, pH 8.7, 22°C Arabidopsis thaliana
1.1.1.22 0.171
-
 UDP-glucose isoform Ugd4, pH 8.7, 22°C Arabidopsis thaliana
1.1.1.22 0.335
-
 UDP-glucose isoform Ugd3, pH 8.7, 22°C Arabidopsis thaliana

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.22 Arabidopsis thaliana
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.22 additional information no substrate: ADP-glucose, TDP-glucose Arabidopsis thaliana ?
-
 ?
1.1.1.22 UDP-glucose + 2 NAD+ + H2O
-
 Arabidopsis thaliana UDP-glucuronate + 2 NADH + 2 H+
-
 ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.1.1.22 1.17
-
 UDP-glucose isoform Ugd4, pH 8.7, 22°C Arabidopsis thaliana
1.1.1.22 1.92
-
 UDP-glucose isoform Ugd2, pH 8.7, 22°C Arabidopsis thaliana
1.1.1.22 2.53
-
 UDP-glucose isoform Ugd3, pH 8.7, 22°C Arabidopsis thaliana

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.22 NAD+ activity with NADP+ is about 20% of that with NAD+ Arabidopsis thaliana
1.1.1.22 NADP+ activity with NADP+ is about 20% of that with NAD+ Arabidopsis thaliana

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.1.1.22 0.083
-
 UDP-xylose isoform Ugd2, pH 8.7, 22°C Arabidopsis thaliana
1.1.1.22 0.16
-
 UDP-xylose isoform Ugd3, pH 8.7, 22°C Arabidopsis thaliana
1.1.1.22 0.22
-
 UDP-xylose isoform Ugd4, pH 8.7, 22°C Arabidopsis thaliana