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Literature summary extracted from

  • Momtaz, S.; Mapunya, B.M.; Houghton, P.J.; Edgerly, C.; Hussein, A.; Naidoo, S.; Lall, N.
    Tyrosinase inhibition by extracts and constituents of Sideroxylon inerme L. stem bark, used in South Africa for skin lightening (2008), J. Ethnopharmacol., 119, 507-512.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.14.18.1 drug development the bark extract of Sideroxylon inerme, epigallocatechin gallate and procyanidin B1 warrant further investigation in clinical studies to be considered as skin-depigmenting agents Agaricus bisporus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.18.1 arbutin
-
 Agaricus bisporus
1.14.18.1 epigallocatechin gallate exhibits a greater anti-tyrosinase activity than arbutin Agaricus bisporus
1.14.18.1 kojic acid
-
 Agaricus bisporus
1.14.18.1 additional information extracts and constituents of Sideroxylon inerme L. stem bark, used in South Africa for skin lightening. Three different extracts (acetone, methanol and dichloromethane) of Sideroxylon inerme L. are evaluated for their inhibitory effect in vitro on the monophenolase and diphenolase activated forms of tyrosinase, using a colorimetric procedure Agaricus bisporus
1.14.18.1 procyanidin B1
-
 Agaricus bisporus

Organism

EC Number Organism UniProt Comment Textmining
1.14.18.1 Agaricus bisporus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.18.1 commercial preparation
-
 Agaricus bisporus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.18.1 L-dopa + 1/2 O2
-
 Agaricus bisporus L-dopaquinone + H2O
-
 ?
1.14.18.1 L-tyrosine + O2 + AH2
-
 Agaricus bisporus L-dopa + H2O + A
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.18.1 tyrosinase
-
 Agaricus bisporus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.14.18.1 additional information
-
 methanolic and acetonic extracts of the stem bark of Sideroxylon inerme show significant inhibition of monophenolase activity (IC50 values of 63 microg/ml and 82 microg/ml). The methanolic extract also exhibits 37% reduction of melanin content at 6.2 microg/ml in melanocytes without being significantly toxic to the cells Agaricus bisporus additional information
1.14.18.1 0.008
-
-
 Agaricus bisporus kojic acid
1.14.18.1 0.0655
-
-
 Agaricus bisporus epigallocatechin gallate
1.14.18.1 0.346
-
-
 Agaricus bisporus procyanidin B1
1.14.18.1 548
-
-
 Agaricus bisporus arbutin