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Literature summary extracted from

  • Choi, J.H.; Rho, M.; Lee, S.W.; Kwon, O.E.; Park, H.R.; Kang, J.Y.; Lee, S.H.; Lee, H.S.; Bae, K.H.; Kim, Y.K.
    Glabrol, an acyl-coenzyme A: cholesterol acyltransferase inhibitor from licorice roots (2007), J. Ethnopharmacol., 110, 563-566.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.3.1.26 pharmacology the data suggest that antiatherosclerotic activity of licorice in hypercholesterolemic patients might be related with its ACAT inhibitory effects Homo sapiens
2.3.1.26 pharmacology the data suggest that antiatherosclerotic activity of licorice in hypercholesterolemic patients might be related with its ACAT inhibitory effects Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.26 glabrol
-
Homo sapiens
2.3.1.26 glabrol
-
Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.26 microsome
-
Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.26 acyl-CoA + cholesterol Homo sapiens
-
CoA + cholesterol ester
-
?
2.3.1.26 acyl-CoA + cholesterol Rattus norvegicus
-
CoA + cholesterol ester
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.26 Homo sapiens
-
-
-
2.3.1.26 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.26 Hep-G2 cell
-
Homo sapiens
-
2.3.1.26 liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.26 acyl-CoA + cholesterol
-
Homo sapiens CoA + cholesterol ester
-
?
2.3.1.26 acyl-CoA + cholesterol
-
Rattus norvegicus CoA + cholesterol ester
-
?
2.3.1.26 oleoyl-CoA + cholesterol activity assay Homo sapiens ?
-
?
2.3.1.26 oleoyl-CoA + cholesterol activity assay Rattus norvegicus ?
-
?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.26 ACAT
-
Homo sapiens
2.3.1.26 ACAT
-
Rattus norvegicus
2.3.1.26 acyl-coenzyme A: cholesterol acyltransferase
-
Homo sapiens
2.3.1.26 acyl-coenzyme A: cholesterol acyltransferase
-
Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.26 37
-
activity assay Homo sapiens
2.3.1.26 37
-
activity assay Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.3.1.26 0.0246
-
-
Rattus norvegicus glabrol
2.3.1.26 0.026
-
-
Homo sapiens glabrol