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Literature summary extracted from

  • Wang, G.F.; Shang, Y.J.; Jiao, B.H.; Huang, C.G.
    Renierol from marine sponge Haliclona sp.: a natural inhibitor of xanthine oxidase with hypouricemic effects (2008), J. Enzyme Inhib. Med. Chem., 23, 406-410.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.17.3.2 renierol a natural enzyme inhibitor from the marine sponge Haliclona sp. Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.17.3.2 hypoxanthine + 2 H2O + 2 O2 Mus musculus production of superoxide radicals urate + 2 H2O2
-
?
1.17.3.2 xanthine + H2O + O2 Mus musculus production of superoxide radicals urate + H2O2
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.17.3.2 Mus musculus
-
male ICR mice
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.3.2 hypoxanthine + 2 H2O + 2 O2 production of superoxide radicals Mus musculus urate + 2 H2O2
-
?
1.17.3.2 xanthine + H2O + O2 production of superoxide radicals Mus musculus urate + H2O2
-
?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.17.3.2 7.5
-
assay at Mus musculus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.17.3.2 1.36 1.85 pH 7.5, inhibition of superoxide and urate production, respectively Mus musculus renierol