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Literature summary extracted from
- pH-dependent inhibition of mushroom tyrosinase by N-substituted N-nitrosohydroxylamines (2008), J. Enzyme Inhib. Med. Chem., 23, 16-20.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.18.1 | 1-cyclopentyl-1-hydroxy-2-oxohydrazine | inhibition of the diphenolase activity of mushroom tyrosinase over the pH range of 5.5-8.0 is studied | Agaricus bisporus |  |
| 1.14.18.1 | 1-dodecyl-1-hydroxy-2-oxohydrazine | inhibition of the diphenolase activity of mushroom tyrosinase over the pH range of 5.5-8.0 is studied | Agaricus bisporus | |
| 1.14.18.1 | 1-hydroxy-1-naphthalen-1-yl-2-oxohydrazine | inhibition of the diphenolase activity of mushroom tyrosinase over the pH range of 5.5-8.0 is studied | Agaricus bisporus | |
| 1.14.18.1 | 1-hydroxy-2-oxo-1-phenylhydrazine | inhibition of the diphenolase activity of mushroom tyrosinase over the pH range of 5.5-8.0 is studied | Agaricus bisporus | |
| 1.14.18.1 | 4-[[hydroxy(nitroso)amino]methyl]benzene-1,3-diol | inhibition of the diphenolase activity of mushroom tyrosinase over the pH range of 5.5-8.0 is studied | Agaricus bisporus | |
| 1.14.18.1 | 4-[[hydroxy(nitroso)amino]methyl]phenol | inhibition of the diphenolase activity of mushroom tyrosinase over the pH range of 5.5-8.0 is studied | Agaricus bisporus | |
| 1.14.18.1 | benzohydroxamic acid | is known to inhibit tyrosinase by chelating with copper. Completely independent of pH | Agaricus bisporus | |
| 1.14.18.1 | benzoic acid | is known to inhibit tyrosinase by chelating with copper. Acts in a similar manner to 1-hydroxy-2-oxo-1-phenylhydrazine | Agaricus bisporus | |
| 1.14.18.1 | kojic acid | is known to inhibit tyrosinase by chelating with copper. Shows only slight pH-dependence of tyrosinase inhibition | Agaricus bisporus | |
| 1.14.18.1 | tropolone | is known to inhibit tyrosinase by chelating with copper. Shows only slight pH-dependence of tyrosinase inhibition | Agaricus bisporus | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.18.1 | Agaricus bisporus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.18.1 | commercial preparation | - |
Agaricus bisporus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.14.18.1 | 6800 | - |
- |
Agaricus bisporus |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.18.1 | polyphenol oxidase | - |
Agaricus bisporus |
| 1.14.18.1 | tyrosinase | - |
Agaricus bisporus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.14.18.1 | 6.8 | - |
relative acitvity at pH 6.8, the activity is almost the same in the range pH 5.5-8.0 | Agaricus bisporus |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.14.18.1 | 4.5 | 9 | the activity of mushrom tyrosinase is studied in this pH range | Agaricus bisporus |
| 1.14.18.1 | 5.5 | 8 | inhibition of the diphenolase activity of mushroom tyrosinase over the pH range of 5.5-8.0 is studied. The observed inhibitory activity at pH 6.8. and 5.8 is approximately 10times and 100times greater than at pH 7.8 | Agaricus bisporus |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 1.14.18.1 | additional information | - |
1-hydroxy-2-oxo-1-phenylhydrazine displays competitive inhibition at pH 6.8 and 5.8, all the other N-substituted N-nitrosohydroxylamines show a different type of inhibition at pH 6.8. and 5.8 | Agaricus bisporus | additional information | |
| 1.14.18.1 | 0.000075 | - |
at pH 5.8 | Agaricus bisporus | 1-cyclopentyl-1-hydroxy-2-oxohydrazine | |
| 1.14.18.1 | 0.00013 | - |
at pH 5.8 | Agaricus bisporus | 1-hydroxy-2-oxo-1-phenylhydrazine | |
| 1.14.18.1 | 0.00026 | - |
at pH 5.8 | Agaricus bisporus | 1-dodecyl-1-hydroxy-2-oxohydrazine | |
| 1.14.18.1 | 0.0006 | - |
at pH 6.8 | Agaricus bisporus | 1-cyclopentyl-1-hydroxy-2-oxohydrazine | |
| 1.14.18.1 | 0.0011 | - |
at pH 5.8 | Agaricus bisporus | 4-[[hydroxy(nitroso)amino]methyl]phenol | |
| 1.14.18.1 | 0.0011 | - |
at pH 6.8 | Agaricus bisporus | 1-hydroxy-2-oxo-1-phenylhydrazine | |
| 1.14.18.1 | 0.0022 | - |
at pH 6.8 | Agaricus bisporus | 1-dodecyl-1-hydroxy-2-oxohydrazine | |
| 1.14.18.1 | 0.0027 | - |
at pH 5.8 | Agaricus bisporus | 4-[[hydroxy(nitroso)amino]methyl]benzene-1,3-diol | |
| 1.14.18.1 | 0.0062 | - |
at pH 5.8 | Agaricus bisporus | 1-hydroxy-1-naphthalen-1-yl-2-oxohydrazine | |
| 1.14.18.1 | 0.0137 | - |
at pH 6.8 | Agaricus bisporus | 4-[[hydroxy(nitroso)amino]methyl]phenol | |
| 1.14.18.1 | 0.0238 | - |
at pH 6.8 | Agaricus bisporus | 4-[[hydroxy(nitroso)amino]methyl]benzene-1,3-diol | |
| 1.14.18.1 | 0.046 | - |
- |
Agaricus bisporus | 1-hydroxy-1-naphthalen-1-yl-2-oxohydrazine | |
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