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Literature summary extracted from

  • Zhang, C.; Lu, Y.; Tao, L.; Tao, X.; Su, X.; Wei, D.
    Tyrosinase inhibitory effects and inhibition mechanisms of nobiletin and hesperidin from citrus peel crude extracts (2007), J. Enzyme Inhib. Med. Chem., 22, 91-98.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.18.1 arbutin inhibitory effect on diphenolase activity of tyrosinase Agaricus bisporus
1.14.18.1 crude ethanol phase ECPE, inhibitory effect on diphenolase activity of tyrosinase Agaricus bisporus
1.14.18.1 hesperidin inhibitory effect on tyrosinase diphenolase, from citrus peel crude extracts Agaricus bisporus
1.14.18.1 kojic acid inhibitory effect on diphenolase activity of tyrosinase Agaricus bisporus
1.14.18.1 macroporus adsorption resin FGRE, inhibitory effect on diphenolase activity of tyrosinase Agaricus bisporus
1.14.18.1 nobiletin inhibitory effect on tyrosinase diphenolase, from citrus peel crude extracts Agaricus bisporus
1.14.18.1 petroleum ether PCPE, inhibitory effect on diphenolase activity of tyrosinase Agaricus bisporus

Organism

EC Number Organism UniProt Comment Textmining
1.14.18.1 Agaricus bisporus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.18.1 commercial preparation
-
 Agaricus bisporus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.14.18.1 3900
-
-
 Agaricus bisporus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.18.1 L-dopa + 1/2 O2
-
 Agaricus bisporus L-dopaquinone + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.18.1 tyrosinase diphenolase
-
 Agaricus bisporus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.14.18.1 2.82
-
 nobiletin
-
 Agaricus bisporus
1.14.18.1 9.16
-
 hesperidin
-
 Agaricus bisporus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.14.18.1 additional information
-
 IC50-value for petroleum ether: 8.09 mg/ml, IC50-value for crude ethanol phase (ECPE): 7.53 mg/ml, IC50-value for macroporus adsorption resin (FGRE): 4.80 mg/ml Agaricus bisporus additional information
1.14.18.1 0.0372
-
-
 Agaricus bisporus kojic acid
1.14.18.1 1.49
-
-
 Agaricus bisporus nobiletin
1.14.18.1 16.08
-
-
 Agaricus bisporus hesperidin
1.14.18.1 27.31
-
-
 Agaricus bisporus arbutin