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Literature summary extracted from

  • Adem, S.; Ciftci, M.
    Effects of some drugs on human erythrocyte 6-phosphogluconate dehydrogenase: an in vitro study (2007), J. Enzyme Inhib. Med. Chem., 22, 751-754.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.44 amoxicillin competitive Homo sapiens
1.1.1.44 clindamycin competitive Homo sapiens
1.1.1.44 Imipenem noncompetitive Homo sapiens
1.1.1.44 lornoxicam noncompetitive Homo sapiens
1.1.1.44 metronidazole noncompetitive Homo sapiens
1.1.1.44 ornidazole noncompetitive Homo sapiens
1.1.1.44 Vancomycin competitive Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.44 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.44
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.44 25.75
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.44 6-phospho-D-gluconate + NADP+
-
 Homo sapiens D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.1.1.44 0.4
-
 lornoxicam 25°C, pH 8.0 Homo sapiens
1.1.1.44 0.57
-
 metronidazole 25°C, pH 8.0 Homo sapiens
1.1.1.44 0.77
-
 Imipenem 25°C, pH 8.0 Homo sapiens
1.1.1.44 42.4
-
 ornidazole 25°C, pH 8.0 Homo sapiens
1.1.1.44 65.6
-
 Vancomycin 25°C, pH 8.0 Homo sapiens
1.1.1.44 130.2
-
 clindamycin 25°C, pH 8.0 Homo sapiens
1.1.1.44 287.6
-
 amoxicillin 25°C, pH 8.0 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.1.44 0.17
-
 25°C, pH 8.0 Homo sapiens lornoxicam
1.1.1.44 0.23
-
 25°C, pH 8.0 Homo sapiens metronidazole
1.1.1.44 0.43
-
 25°C, pH 8.0 Homo sapiens Imipenem
1.1.1.44 21.79
-
 25°C, pH 8.0 Homo sapiens ornidazole
1.1.1.44 46.39
-
 25°C, pH 8.0 Homo sapiens Vancomycin
1.1.1.44 117.4
-
 25°C, pH 8.0 Homo sapiens clindamycin
1.1.1.44 287.4
-
 25°C, pH 8.0 Homo sapiens amoxicillin