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Literature summary extracted from
- Homocysteine effects on cellular glutathione peroxidase (GPx-1) activity under in vitro conditions (2007), J. Enzyme Inhib. Med. Chem., 22, 733-738.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.11.1.9 | cysteine | cysteine increases activity at low glutathione concentrations | Bos taurus |  |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.11.1.9 | cysteine | GPx-1 is inhibited by 0.5 mM cysteine | Bos taurus | |
| 1.11.1.9 | homocysteine | GPx-1 is inhibited by 0.05-0.5 mM homocysteine, especially at low glutathione concentrations | Bos taurus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.11.1.9 | cytosol | - |
Bos taurus | 5829 | - |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.11.1.9 | Bos taurus | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.11.1.9 | H2O2 + GSH | - |
Bos taurus | H2O + GSSG | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.11.1.9 | Cellular glutathione peroxidase | - |
Bos taurus |
| 1.11.1.9 | G-6137 | commercial preparation | Bos taurus |
| 1.11.1.9 | Gpx-1 | - |
Bos taurus |
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Release 2023.1 (January 2023)
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