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Literature summary extracted from

  • Borisov, A.B.; Raeker, M.O.; Russell, M.W.
    Developmental expression and differential cellular localization of obscurin and obscurin-associated kinase in cardiac muscle cells (2008), J. Cell. Biochem., 103, 1621-1635.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.18 additional information activation of the RhoA pathway can inhibit myosin phosphatase activity, thereby enhancing the effects of the kinase-mediated phosphorylation of myosin light chain Mus musculus
2.7.11.18 additional information activation of the RhoA pathway can inhibit myosin phosphatase activity, thereby enhancing the effects of the kinase-mediated phosphorylation of myosin light chain Homo sapiens
2.7.11.18 additional information activation of the RhoA pathway can inhibit myosin phosphatase activity, thereby enhancing the effects of the kinase-mediated phosphorylation of myosin light chain Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.18 obscurin-associated kinase, DNA and amino acid sequence determination, sequence and expression analysis and comparison, both the mouse and human obscurinassociated kinase-like transcripts also share a conserved putative translation initiation site, overview. Expression in Escherichia coli strain BL21(DE3) Homo sapiens
2.7.11.18 sequence and expression analysis and comparison, both the mouse and human obscurinassociated kinase-like transcripts also share a conserved putative translation initiation site, overview Mus musculus
2.7.11.18 sequence and expression analysis and comparison, overview Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.18 additional information PAK phosphorylation of MLCK by p21-activated kinase, a kinase activated by the Rho family of GTPases, can inhibit MLCK activity Homo sapiens
2.7.11.18 additional information PAK phosphorylation of MLCK by p21-activated kinase, a kinase activated by the Rho family of GTPases, can inhibit MLCK activity Mus musculus
2.7.11.18 additional information PAK phosphorylation of MLCK by p21-activated kinase, a kinase activated by the Rho family of GTPases, can inhibit MLCK activity Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.18 cytoplasm exclusively Mus musculus 5737
-
2.7.11.18 cytoplasm exclusively Homo sapiens 5737
-
2.7.11.18 cytoplasm exclusively Rattus norvegicus 5737
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.18 Ca2+
-
 Mus musculus
2.7.11.18 Ca2+
-
 Homo sapiens
2.7.11.18 Ca2+
-
 Rattus norvegicus
2.7.11.18 Mg2+
-
 Mus musculus
2.7.11.18 Mg2+
-
 Homo sapiens
2.7.11.18 Mg2+
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.18 ATP + myosin light chain Mus musculus the MLCK family plays an essential role in regulation of actin/myosin organization, sarcomere assembly and cytoskeletal dynamics ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain Homo sapiens the MLCK family plays an essential role in regulation of actin/myosin organization, sarcomere assembly and cytoskeletal dynamics ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain Rattus norvegicus the MLCK family plays an essential role in regulation of actin/myosin organization, sarcomere assembly and cytoskeletal dynamics ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + obscurin Mus musculus
-
 ADP + obscurin phosphate
-
 ?
2.7.11.18 ATP + obscurin Homo sapiens
-
 ADP + obscurin phosphate
-
 ?
2.7.11.18 ATP + obscurin Rattus norvegicus
-
 ADP + obscurin phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.18 Homo sapiens
-
-
-
2.7.11.18 Mus musculus
-
-
-
2.7.11.18 Rattus norvegicus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.18 phosphoprotein PAK phosphorylation of MLCK by p21- activated kinase, a kinase activated by the Rho family of GTPases, can inhibit MLCK activity Mus musculus
2.7.11.18 phosphoprotein PAK phosphorylation of MLCK by p21- activated kinase, a kinase activated by the Rho family of GTPases, can inhibit MLCK activity Homo sapiens
2.7.11.18 phosphoprotein PAK phosphorylation of MLCK by p21- activated kinase, a kinase activated by the Rho family of GTPases, can inhibit MLCK activity Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.18 cardiac myocyte primary cell culture Mus musculus
-
2.7.11.18 cardiac myocyte primary cell culture Homo sapiens
-
2.7.11.18 cardiac myocyte primary cell culture Rattus norvegicus
-
2.7.11.18 heart ventricle Mus musculus
-
2.7.11.18 heart ventricle Homo sapiens
-
2.7.11.18 heart ventricle Rattus norvegicus
-
2.7.11.18 additional information developmental pattern of obscurin and obscurin-associated kinase expression, overview Mus musculus
-
2.7.11.18 additional information developmental pattern of obscurin and obscurin-associated kinase expression, overview Homo sapiens
-
2.7.11.18 additional information developmental pattern of obscurin and obscurin-associated kinase expression, overview Rattus norvegicus
-
2.7.11.18 muscle expression of obscurin-MLCK-like kinase is restricted to muscles in the myonucleus Mus musculus
-
2.7.11.18 muscle expression of obscurin-MLCK-like kinase is restricted to muscles in the myonucleus Homo sapiens
-
2.7.11.18 muscle expression of obscurin-MLCK-like kinase is restricted to muscles in the myonucleus Rattus norvegicus
-
2.7.11.18 myocardium expression analysis, overview Mus musculus
-
2.7.11.18 myocardium expression analysis, overview Homo sapiens
-
2.7.11.18 myocardium expression analysis, overview Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.18 ATP + myosin light chain
-
 Mus musculus ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain
-
 Homo sapiens ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain
-
 Rattus norvegicus ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain the MLCK family plays an essential role in regulation of actin/myosin organization, sarcomere assembly and cytoskeletal dynamics Mus musculus ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain the MLCK family plays an essential role in regulation of actin/myosin organization, sarcomere assembly and cytoskeletal dynamics Homo sapiens ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain the MLCK family plays an essential role in regulation of actin/myosin organization, sarcomere assembly and cytoskeletal dynamics Rattus norvegicus ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + obscurin
-
 Mus musculus ADP + obscurin phosphate
-
 ?
2.7.11.18 ATP + obscurin
-
 Homo sapiens ADP + obscurin phosphate
-
 ?
2.7.11.18 ATP + obscurin
-
 Rattus norvegicus ADP + obscurin phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.18 MLCK
-
 Mus musculus
2.7.11.18 MLCK
-
 Homo sapiens
2.7.11.18 MLCK
-
 Rattus norvegicus
2.7.11.18 myosin light chain kinase
-
 Mus musculus
2.7.11.18 myosin light chain kinase
-
 Homo sapiens
2.7.11.18 myosin light chain kinase
-
 Rattus norvegicus
2.7.11.18 obscurin-associated kinase
-
 Mus musculus
2.7.11.18 obscurin-associated kinase
-
 Homo sapiens
2.7.11.18 obscurin-associated kinase
-
 Rattus norvegicus
2.7.11.18 obscurin-MLCK-like kinase
-
 Mus musculus
2.7.11.18 obscurin-MLCK-like kinase
-
 Homo sapiens
2.7.11.18 obscurin-MLCK-like kinase
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.18 ATP
-
 Mus musculus
2.7.11.18 ATP
-
 Homo sapiens
2.7.11.18 ATP
-
 Rattus norvegicus