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Literature summary extracted from

  • Gey, U.; Czupalla, C.; Hoflack, B.; Roedel, G.; Krause-Buchholz, U.
    Yeast pyruvate dehydrogenase complex is regulated by a concerted activity of two kinases and two phosphatases (2008), J. Biol. Chem., 283, 9759-9767.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.2.1.104 PDC phosphatase II dephosphorylates and reactivates phosphorylated Pda1p Saccharomyces cerevisiae
1.2.1.104 protein Ppp1p dephosphorylates and reactivates phosphorylated Pda1p Saccharomyces cerevisiae
3.1.3.43 additional information Pkp2p (Ygl059wp) and Ppp2p (Ycr079wp), but not Yhr076w, are engaged in the regulation of the pyruvate dehydrogenase complex by affecting the phosphorylation state of subunit Pda1p Saccharomyces cerevisiae

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.104 PDC kinase II phosphorylates and inactivates Pda1p Saccharomyces cerevisiae
1.2.1.104 protein Pkp1p phosphorylates and inactivates Pda1p Saccharomyces cerevisiae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.1.104 mitochondrion
-
 Saccharomyces cerevisiae 5739
-
3.1.3.43 mitochondrion
-
 Saccharomyces cerevisiae 5739
-

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.104 Saccharomyces cerevisiae
-
-
-
1.2.1.104 Saccharomyces cerevisiae BY4741
-
-
-
3.1.3.43 Saccharomyces cerevisiae
-
-
-
3.1.3.43 Saccharomyces cerevisiae BY4741
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.104 pyruvate + CoA + NAD+
-
 Saccharomyces cerevisiae acetyl-CoA + CO2 + NADH
-
 ?
1.2.1.104 pyruvate + CoA + NAD+
-
 Saccharomyces cerevisiae BY4741 acetyl-CoA + CO2 + NADH
-
 ?
1.2.1.104 pyruvate + lipoamide
-
 Saccharomyces cerevisiae S-acetyldihydrolipoamide + CO2
-
 ?
1.2.1.104 pyruvate + lipoamide
-
 Saccharomyces cerevisiae BY4741 S-acetyldihydrolipoamide + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.1.104 Pda1p alpha subunit of the pyruvate dehydrogenase complex Saccharomyces cerevisiae
3.1.3.43 Pda1p alpha-subunit of the pyruvate dehydrogenase complex Saccharomyces cerevisiae
3.1.3.43 PDC
-
 Saccharomyces cerevisiae
3.1.3.43 pyruvate dehydrogenase complex
-
 Saccharomyces cerevisiae

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.104 NAD+
-
 Saccharomyces cerevisiae
1.2.1.104 thiamine diphosphate
-
 Saccharomyces cerevisiae