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Literature summary extracted from

  • Fisher, A.L.; Page, K.E.; Lithgow, G.J.; Nash, L.
    The Caenorhabditis elegans K10C2.4 gene encodes a member of the fumarylacetoacetate hydrolase family: a Caenorhabditis elegans model of type I tyrosinemia (2008), J. Biol. Chem., 283, 9127-9135.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.7.1.2 medicine type I tyrosinemia is caused by mutations in the fumarylacetoacetate hydrolase gene, the results establish worms as a model for the study of type I tyrosinemia Caenorhabditis elegans

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.7.1.2 additional information RNAi directed against the K10C2.4 gene, encoding fumarylacetoacetate hydrolase, produces a lethal phenotype Caenorhabditis elegans

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.7.1.2 46000
-
 predicted molecular weight, verified by SDS-PAGE and Western blot Caenorhabditis elegans

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.7.1.2 4-fumarylacetoacetate + H2O Caenorhabditis elegans
-
 acetoacetate + fumarate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.7.1.2 Caenorhabditis elegans Q94272
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.7.1.2 4-fumarylacetoacetate + H2O
-
 Caenorhabditis elegans acetoacetate + fumarate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.7.1.2 FAH
-
 Caenorhabditis elegans
3.7.1.2 fumarylacetoacetase
-
 Caenorhabditis elegans
3.7.1.2 fumarylacetoacetate hydrolase
-
 Caenorhabditis elegans