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Literature summary extracted from

  • Vodnala, M.; Fijolek, A.; Rofougaran, R.; Mosimann, M.; Maeser, P.; Hofer, A.
    Adenosine kinase mediates high affinity adenosine salvage in Trypanosoma brucei (2008), J. Biol. Chem., 283, 5380-5388.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.20 phosphate stimulates Trypanosoma brucei

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.20 expression in Escherichia coli Trypanosoma brucei

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.20 adenosine
-
 Trypanosoma brucei

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.20 0.000041
-
 adenosine pH 7.6, 37°C Trypanosoma brucei
2.7.1.20 0.013
-
 cordycepin pH 7.6, 37°C Trypanosoma brucei
2.7.1.20 0.026
-
 ATP pH 7.6, 37°C Trypanosoma brucei
2.7.1.20 0.082
-
 GTP pH 7.6, 37°C Trypanosoma brucei
2.7.1.20 0.11
-
 deoxyadenosine pH 7.6, 37°C Trypanosoma brucei
2.7.1.20 0.34
-
 UTP pH 7.6, 37°C Trypanosoma brucei
2.7.1.20 0.54
-
 fludarabine pH 7.6, 37°C Trypanosoma brucei
2.7.1.20 0.57
-
 Inosine pH 7.6, 37°C Trypanosoma brucei
2.7.1.20 0.61
-
 CTP pH 7.6, 37°C Trypanosoma brucei

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.20 MgCl2 required Trypanosoma brucei

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.20 Trypanosoma brucei
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.20
-
 Trypanosoma brucei

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.20 ATP + adenosine
-
 Trypanosoma brucei ADP + AMP
-
 ?
2.7.1.20 ATP + cordycepin
-
 Trypanosoma brucei ADP + cordycepin 5'-phosphate
-
 ?
2.7.1.20 ATP + deoxyadenosine
-
 Trypanosoma brucei ADP + deoxyadenosine 5'-phosphate
-
 ?
2.7.1.20 ATP + fludarabine
-
 Trypanosoma brucei ADP + fludarabine 5'-phosphate
-
 ?
2.7.1.20 ATP + inosine
-
 Trypanosoma brucei ADP + inosine 5'-phosphate
-
 ?
2.7.1.20 CTP + adenosine
-
 Trypanosoma brucei CDP + AMP
-
 ?
2.7.1.20 GTP + adenosine
-
 Trypanosoma brucei GDP + AMP
-
 ?
2.7.1.20 UTP + adenosine
-
 Trypanosoma brucei UDP + AMP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.20 TbAK
-
 Trypanosoma brucei

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.7.1.20 0.11
-
 fludarabine pH 7.6, 37°C Trypanosoma brucei
2.7.1.20 1.1
-
 Inosine pH 7.6, 37°C Trypanosoma brucei
2.7.1.20 3.9
-
 cordycepin pH 7.6, 37°C Trypanosoma brucei
2.7.1.20 4.2
-
 deoxyadenosine pH 7.6, 37°C Trypanosoma brucei
2.7.1.20 7.3
-
 ATP pH 7.6, 37°C Trypanosoma brucei
2.7.1.20 8.1
-
 adenosine pH 7.6, 37°C Trypanosoma brucei
2.7.1.20 16
-
 GTP pH 7.6, 37°C Trypanosoma brucei
2.7.1.20 18
-
 UTP pH 7.6, 37°C Trypanosoma brucei
2.7.1.20 20
-
 CTP pH 7.6, 37°C Trypanosoma brucei

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.20 8
-
-
 Trypanosoma brucei

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.7.1.20 6 9.5 pH 6.0: about 70% of maximal activity, pH 9.5: about 60% of maximal activity Trypanosoma brucei

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.1.20 0.014
-
 adenosine pH 7.6, 37°C Trypanosoma brucei