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Literature summary extracted from

  • Schiefelbein, D.; Goren, I.; Fisslthaler, B.; Schmidt, H.; Geisslinger, G.; Pfeilschifter, J.; Frank, S.
    Biphasic regulation of HMG-CoA reductase expression and activity during wound healing and its functional role in the control of keratinocyte angiogenic and proliferative responses (2008), J. Biol. Chem., 283, 15479-15490.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.34 simvastatin enzyme inhibition causes 40% reduction of wound healing, inhibition of HMGR activity during acute wound healing interferes with keratinocyte VEGF production and proliferation at the wound site, overview Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.34 microsome
-
 Mus musculus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.34 hydroxymethylglutaryl-CoA + NADPH + H+ Mus musculus
-
 mevalonate + NADP+ + CoA
-
 ?
1.1.1.34 hydroxymethylglutaryl-CoA + NADPH + H+ Mus musculus C57/BL6J
-
 mevalonate + NADP+ + CoA
-
 ?
1.1.1.34 additional information Mus musculus biphasic regulation of HMG-CoA reductase expression and activity during wound healing and its functional role in the control of keratinocyte angiogenic and proliferative responses, overview ?
-
 ?
1.1.1.34 additional information Mus musculus C57/BL6J biphasic regulation of HMG-CoA reductase expression and activity during wound healing and its functional role in the control of keratinocyte angiogenic and proliferative responses, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.34 Mus musculus
-
 C57BL/6J mice
-
1.1.1.34 Mus musculus C57/BL6J
-
 C57BL/6J mice
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.34 keratinocyte
-
 Mus musculus
-
1.1.1.34 skin from tail Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.34 hydroxymethylglutaryl-CoA + NADPH + H+
-
 Mus musculus mevalonate + NADP+ + CoA
-
 ?
1.1.1.34 hydroxymethylglutaryl-CoA + NADPH + H+
-
 Mus musculus C57/BL6J mevalonate + NADP+ + CoA
-
 ?
1.1.1.34 additional information biphasic regulation of HMG-CoA reductase expression and activity during wound healing and its functional role in the control of keratinocyte angiogenic and proliferative responses, overview Mus musculus ?
-
 ?
1.1.1.34 additional information biphasic regulation of HMG-CoA reductase expression and activity during wound healing and its functional role in the control of keratinocyte angiogenic and proliferative responses, overview Mus musculus C57/BL6J ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.34 HMGR
-
 Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.34 37
-
 assay at Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.34 7.4
-
 assay at Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.34 NADPH
-
 Mus musculus