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Literature summary extracted from

  • Malaga, W.; Constant, P.; Euphrasie, D.; Cataldi, A.; Daffe, M.; Reyrat, J.M.; Guilhot, C.
    Deciphering the genetic bases of the structural diversity of phenolic glycolipids in strains of the Mycobacterium tuberculosis complex (2008), J. Biol. Chem., 283, 15177-15184.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.271 DNA and amino acid sequence determination and analysis, enzyme expression in Mycobacterium bovis leads to restoration of wild-type phenotype producing triglycosylated phenolic glycolipids instead of monoglycosylated as in the mutant, mass spectrometric lipid spectrum analysis, overview Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.271 GDP-4-dehydro-6-deoxy-D-mannose + NADPH Mycobacterium tuberculosis the enzyme is required for the formation of activated L-fucose GDP-L-fucose + NADP+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.271 Mycobacterium tuberculosis
-
-
-
1.1.1.271 no activity in Mycobacterium bovis
-
 due to a natural mutation deleting the gene encoding the enzyme
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.271 GDP-4-dehydro-6-deoxy-D-mannose + NADPH
-
 Mycobacterium tuberculosis GDP-L-fucose + NADP+
-
 r
1.1.1.271 GDP-4-dehydro-6-deoxy-D-mannose + NADPH the enzyme is required for the formation of activated L-fucose Mycobacterium tuberculosis GDP-L-fucose + NADP+
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.1.1.271 GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase/reductase
-
 Mycobacterium tuberculosis