EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.6.3.1 | formyl-Met-Leu-Phe | stimulation. In addition, heterologous expression of subunit p40phox markedly enhances superoxide production in stimulated cells. Upon stimulation with phorbol 12-myristate 13-acetate or formyl-Met-Leu-Phe, p40phox translocates to plasma membrane in a p67phox- and p47phox-dependent manner | Homo sapiens | |
1.6.3.1 | phorbol 12-myristate 13-acetate | stimulation. In addition, heterologous expression of subunit p40phox markedly enhances superoxide production in stimulated cells. Upon stimulation with phorbol 12-myristate 13-acetate or formyl-Met-Leu-Phe, p40phox translocates to plasma membrane in a p67phox- and p47phox-dependent manner | Homo sapiens |
EC Number | Cloned (Comment) | Organism |
---|---|---|
1.6.3.1 | stable transfection of COS-7 cells of subunits gp91phox, p22phox, p67phox, p47phox, and also p40phox fused to the N-terminus of green fluorescent protein | Homo sapiens |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
1.6.3.1 | R57Q | mutation in the phophatidylinositol 3-phosphate binding region of subunit p47phox. Mutation abrogates phophatidylinositol 3-phosphate binding and produces a dominant inhibitory effect on agonist-induced superoxide production and membrane translocation of subunits p47phox and p67phox. Mutant p40phox displayes increased association with actin and moesin and is found enriched in the Triton X-100-insoluble fraction along with p67phox and p47phox | Homo sapiens |
1.6.3.1 | R57Q/D289A | double mutant of subunit p40phox. Mutant fails to associate with subunits p67phox or p47phox in co-immunoprecipitation and Western blotting assays and abolishes the dominant inhibitory effect of mutant R57Q in phorbol 12-myristate 13-acetate- or formyl-Met-Leu-Phe-induced superoxide production | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.6.3.1 | cytoplasm | full-length subunit p40phox exhibits a cytoplasmic localization pattern in resting cells. Upon stimulation with phorbol 12-myristate 13-acetate or formyl-Met-Leu-Phe, p40phox translocates to plasma membrane in a p67phox- and p47phox-dependent manner | Homo sapiens | 5737 | - |
1.6.3.1 | plasma membrane | full-length subunit p40phox exhibits a cytoplasmic localization pattern in resting cells. Upon stimulation with phorbol 12-myristate 13-acetate or formyl-Met-Leu-Phe, p40phox translocates to plasma membrane in a p67phox- and p47phox-dependent manner | Homo sapiens | 5886 | - |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.6.3.1 | Homo sapiens | - |
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