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Literature summary extracted from
- Human peroxiredoxin 1 and 2 are not duplicate proteins: the unique presence of Cys83 in Prx1 underscores the structural and functional differences between Prx1 and Prx2 (2007), J. Biol. Chem., 282, 22011-22022.
Crystallization (Commentary)
| EC Number | Crystallization (Comment) | Organism |
|---|---|---|
| 1.11.1.24 | hanging drop vapour diffusion method with 100 mM citrate (pH 4.6) and 10% polyethylene glycol | Homo sapiens |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 1.11.1.24 | C83S | increased activity compared to wild type Prx1 | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.11.1.24 | H2O2 | highly susceptible to inactivation by H2O2; highly susceptible to inactivation by H2O2 | Homo sapiens |  |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.11.1.24 | 43630 | - |
Prx2, Q-TOF mass spectrometry | Homo sapiens |
| 1.11.1.24 | 219700 | - |
Prx1, Q-TOF mass spectrometry | Homo sapiens |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.11.1.24 | Homo sapiens | P32119 | - |
- |
| 1.11.1.24 | Homo sapiens | Q06830 | - |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.11.1.24 | DEAE-Sepharose column chromatography, SP-Sepharose column chromatography, and Superdex 200 gel filtration | Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.11.1.24 | H2O2 + reduced dithiothreitol | - |
Homo sapiens | H2O + oxidized dithiothreitol | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.11.1.24 | decamer | Prx1, X-ray crystallography | Homo sapiens |
| 1.11.1.24 | dimer | Prx2, X-ray crystallography | Homo sapiens |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.11.1.24 | peroxiredoxin 1 | - |
Homo sapiens |
| 1.11.1.24 | peroxiredoxin 2 | - |
Homo sapiens |
| 1.11.1.24 | Prx1 | - |
Homo sapiens |
| 1.11.1.24 | Prx2 | - |
Homo sapiens |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.11.1.24 | thioredoxin | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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