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Literature summary extracted from

  • Martens, G.A.; Vervoort, A.; Van de Casteele, M.; Stange, G.; Hellemans, K.; Van Thi, H.V.; Schuit, F.; Pipeleers, D.
    Specificity in beta cell expression of L-3-hydroxyacyl-CoA dehydrogenase, short chain, and potential role in down-regulating insulin release (2007), J. Biol. Chem., 282, 21134-21144.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.1.1.35 additional information inactivation of the enzyme by siRNA expression, the mutants show reduced beta-oxidation of fatty acids Homo sapiens
1.1.1.35 additional information inactivation of the enzyme by siRNA expression, the mutants show reduced beta-oxidation of fatty acids, shRNA-mediated HADHSC silencing affects induced absolute and fractional insulin secretion in INS1 832-13 cells and the cellular insulin content, overview Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.35 mitochondrion
-
 Homo sapiens 5739
-
1.1.1.35 mitochondrion
-
 Rattus norvegicus 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.35 34000
-
 x * 34000, SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.35 (S)-3-hydroxyacyl-CoA + NAD+ Homo sapiens the enzyme is involved in fatty acid beta-oxidation in beta cells, overview 3-oxoacyl-CoA + NADH + H+
-
 ?
1.1.1.35 (S)-3-hydroxyacyl-CoA + NAD+ Rattus norvegicus the enzyme is involved in fatty acid beta-oxidation in beta cells, overview 3-oxoacyl-CoA + NADH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.35 Homo sapiens
-
-
-
1.1.1.35 Rattus norvegicus
-
-
-
1.3.8.1 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.35 pancreas immunohistochemic analysis, more intense staining in islets than in the surrounding exocrine tissue, being strongly present in insulin-positive cells and only weakly in glucagon-positive alpha cells Homo sapiens
-
1.1.1.35 pancreatic beta cell primary Homo sapiens
-
1.1.1.35 pancreatic beta cell primary Rattus norvegicus
-
1.3.8.1 hepatocyte
-
 Rattus norvegicus
-
1.3.8.1 INS-1 832/13 cell
-
 Rattus norvegicus
-
1.3.8.1 pancreatic beta cell low expression of ACADS during high expression of L-3-hydroxyacyl-CoA dehydrogenase short chain Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.35 (S)-3-hydroxyacyl-CoA + NAD+
-
 Homo sapiens 3-oxoacyl-CoA + NADH + H+
-
 ?
1.1.1.35 (S)-3-hydroxyacyl-CoA + NAD+
-
 Rattus norvegicus 3-oxoacyl-CoA + NADH + H+
-
 ?
1.1.1.35 (S)-3-hydroxyacyl-CoA + NAD+ the enzyme is involved in fatty acid beta-oxidation in beta cells, overview Homo sapiens 3-oxoacyl-CoA + NADH + H+
-
 ?
1.1.1.35 (S)-3-hydroxyacyl-CoA + NAD+ the enzyme is involved in fatty acid beta-oxidation in beta cells, overview Rattus norvegicus 3-oxoacyl-CoA + NADH + H+
-
 ?
1.3.8.1 butyryl-CoA + electron acceptor
-
 Rattus norvegicus 2-butenoyl-CoA + reduced acceptor
-
 ?

Subunits

EC Number Subunits Comment Organism
1.1.1.35 ? x * 34000, SDS-PAGE Rattus norvegicus

Synonyms

EC Number Synonyms Comment Organism
1.1.1.35 HADHSC
-
 Homo sapiens
1.1.1.35 HADHSC
-
 Rattus norvegicus
1.1.1.35 L-3-hydroxyacyl-CoA dehydrogenase, short chain
-
 Homo sapiens
1.1.1.35 L-3-hydroxyacyl-CoA dehydrogenase, short chain
-
 Rattus norvegicus
1.3.8.1 ACADS
-
 Rattus norvegicus
1.3.8.1 acyl-CoA dehydrogenase short chain
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.35 NAD+
-
 Homo sapiens
1.1.1.35 NAD+
-
 Rattus norvegicus