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Literature summary extracted from
- A second fatty acid amide hydrolase with variable distribution among placental mammals (2006), J. Biol. Chem., 281, 36569-36578.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.5.1.4 | 3'-(aminocarbonyl)biphenyl-3-yl cyclohexylcarbamate | - |
Homo sapiens |  |
| 3.5.1.4 | 3'-carbamoylbiphenyl-3-yl undec-10-yn-1-ylcarbamate | - |
Homo sapiens | |
| 3.5.1.4 | 4-(benzyloxy)phenyl butylcarbamate | - |
Homo sapiens | |
| 3.5.1.4 | 7-phenyl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one | - |
Homo sapiens | |
| 3.5.1.99 | 3'-carbamoylbiphenyl-3-yl cyclohexylcarbamate | - |
Homo sapiens | |
| 3.5.1.99 | 3'-carbamoylbiphenyl-3-yl undec-10-yn-1-ylcarbamate | - |
Homo sapiens | |
| 3.5.1.99 | 4-(benzyloxy)phenyl butylcarbamate | - |
Homo sapiens | |
| 3.5.1.99 | 7-phenyl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one | - |
Homo sapiens | |
| 3.5.1.99 | JP104 | - |
Homo sapiens | |
| 3.5.1.99 | OL-135 | - |
Homo sapiens | |
| 3.5.1.99 | URB532 | - |
Homo sapiens | |
| 3.5.1.99 | URB597 | - |
Homo sapiens | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.5.1.4 | membrane | FAAH-1 shows predominantly cytoplasmic orientation | Homo sapiens | 16020 | - |
| 3.5.1.4 | membrane | FAAH-2 is luminally orientated in the membrane | Homo sapiens | 16020 | - |
| 3.5.1.99 | membrane | FAAH-2 is luminally orientated in the membrane | Homo sapiens | 16020 | - |
| 3.5.1.99 | membrane | FAAH-1 shows a predominantly cytoplasmic orientation in the membrane | Homo sapiens | 16020 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.5.1.4 | additional information | Homo sapiens | FAAH-1 plays a primary role in regulating endocannabinoid signaling | ? | - |
? | |
| 3.5.1.99 | anandamide + H2O | Homo sapiens | FAAH-1 plays a primary role in regulating endocannabinoid signaling | ethanolamine + arachidonic acid | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.5.1.4 | Homo sapiens | O00519 | from COS-7 cells transfected with human FAAH-1 | - |
| 3.5.1.4 | Homo sapiens | Q6GMR7 | from COS-7 cells transfected with human FAAH-1 | - |
| 3.5.1.99 | Homo sapiens | O00519 | - |
- |
| 3.5.1.99 | Homo sapiens | Q6GMR7 | - |
- |
| 3.5.1.99 | Mus musculus | O08914 | - |
- |
| 3.5.1.99 | Rattus norvegicus | P97612 | - |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.5.1.4 | brain | FAAH-1 is highly expressed | Homo sapiens | - |
| 3.5.1.4 | heart | FAAH-2 | Homo sapiens | - |
| 3.5.1.4 | kidney | FAAH-1 | Homo sapiens | - |
| 3.5.1.4 | kidney | FAAH-2 | Homo sapiens | - |
| 3.5.1.4 | liver | FAAH-1 | Homo sapiens | - |
| 3.5.1.4 | liver | FAAH-2 | Homo sapiens | - |
| 3.5.1.4 | lung | FAAH-1 | Homo sapiens | - |
| 3.5.1.4 | lung | FAAH-2 | Homo sapiens | - |
| 3.5.1.4 | additional information | no FAAH-1 activity is detected in heart | Homo sapiens | - |
| 3.5.1.4 | prostate | FAAH-1 | Homo sapiens | - |
| 3.5.1.4 | prostate | FAAH-2 | Homo sapiens | - |
| 3.5.1.4 | small intestine | FAAH-1 is highly expressed | Homo sapiens | - |
| 3.5.1.4 | testis | FAAH-1 is highly expressed | Homo sapiens | - |
| 3.5.1.99 | brain | - |
Homo sapiens | - |
| 3.5.1.99 | heart | highly expressed | Homo sapiens | - |
| 3.5.1.99 | kidney | - |
Homo sapiens | - |
| 3.5.1.99 | liver | - |
Homo sapiens | - |
| 3.5.1.99 | lung | - |
Homo sapiens | - |
| 3.5.1.99 | MCF-7 cell | - |
Homo sapiens | - |
| 3.5.1.99 | additional information | no activity in brain, small intestine and testis | Homo sapiens | - |
| 3.5.1.99 | additional information | no activity in heart | Homo sapiens | - |
| 3.5.1.99 | OVCAR-3 cell | - |
Homo sapiens | - |
| 3.5.1.99 | prostate | - |
Homo sapiens | - |
| 3.5.1.99 | small intestine | - |
Homo sapiens | - |
| 3.5.1.99 | testis | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.5.1.4 | anandamide + H2O | FAAH-1 | Homo sapiens | arachidonic acid + ethanolamine | - |
? | |
| 3.5.1.4 | anandamide + H2O | FAAH-2 | Homo sapiens | arachidonic acid + ethanolamine | - |
? | |
| 3.5.1.4 | additional information | FAAH-1 plays a primary role in regulating endocannabinoid signaling | Homo sapiens | ? | - |
? | |
| 3.5.1.4 | additional information | no FAAH-2 activity is detected with N-oleoyl taurine | Homo sapiens | ? | - |
? | |
| 3.5.1.4 | N-oleoyl ethanolamine + H2O | FAAH-1 | Homo sapiens | oleic acid + ethanolamine | - |
? | |
| 3.5.1.4 | N-oleoyl ethanolamine + H2O | FAAH-2 | Homo sapiens | oleic acid + ethanolamine | - |
? | |
| 3.5.1.4 | N-oleoyl taurine + H2O | FAAH-1 | Homo sapiens | oleic acid + taurine | - |
? | |
| 3.5.1.4 | N-palmitolyl ethanolamine + H2O | FAAH-1 | Homo sapiens | palmitic acid + ethanolamine | - |
? | |
| 3.5.1.4 | N-palmitolyl ethanolamine + H2O | FAAH-2 | Homo sapiens | palmitic acid + ethanolamine | - |
? | |
| 3.5.1.4 | oleamide + H2O | FAAH-1 | Homo sapiens | oleic acid + NH3 | - |
? | |
| 3.5.1.4 | oleamide + H2O | FAAH-2 | Homo sapiens | oleic acid + NH3 | - |
? | |
| 3.5.1.99 | anandamide + H2O | - |
Homo sapiens | ethanolamine + arachidonic acid | - |
? | |
| 3.5.1.99 | anandamide + H2O | FAAH-1 plays a primary role in regulating endocannabinoid signaling | Homo sapiens | ethanolamine + arachidonic acid | - |
? | |
| 3.5.1.99 | anandamide + H2O | 5% of the activity with oleamide | Homo sapiens | ethanolamine + arachidonic acid | - |
? | |
| 3.5.1.99 | additional information | no activity with N-oleoyltaurine | Homo sapiens | ? | - |
? | |
| 3.5.1.99 | N-oleoylethanolamine + H2O | 23% of the activity with oleamide | Homo sapiens | oleic acid + ethanolamine | - |
? | |
| 3.5.1.99 | N-oleoylethanolamine + H2O | 33% of the activity with anandamide | Homo sapiens | oleic acid + ethanolamine | - |
? | |
| 3.5.1.99 | N-oleoyltaurine + H2O | 4% of the activity with anandamide | Homo sapiens | taurine + oleic acid | - |
? | |
| 3.5.1.99 | N-palmitoylethanolamine + H2O | 12% of the activity with anandamide | Homo sapiens | palmitic acid + ethanolamine | - |
? | |
| 3.5.1.99 | N-palmitoylethanolamine + H2O | 2.3% of the activity with oleamide | Homo sapiens | palmitic acid + ethanolamine | - |
? | |
| 3.5.1.99 | oleamide + H2O | - |
Homo sapiens | oleic acid + NH3 | - |
? | |
| 3.5.1.99 | oleamide + H2O | 57% of the activity with anandamide | Homo sapiens | oleic acid + NH3 | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.5.1.4 | FAAH-1 | - |
Homo sapiens |
| 3.5.1.4 | FAAH-2 | - |
Homo sapiens |
| 3.5.1.4 | fatty acid amide hydrolase | - |
Homo sapiens |
| 3.5.1.99 | FAAH-1 | - |
Mus musculus |
| 3.5.1.99 | FAAH-1 | - |
Rattus norvegicus |
| 3.5.1.99 | FAAH-1 | - |
Homo sapiens |
| 3.5.1.99 | FAAH-2 | - |
Homo sapiens |
| 3.5.1.99 | FAAH-2 | FAAH-2 is an ancient gene present in primates, but not murids | Homo sapiens |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 3.5.1.4 | 0.00000038 | - |
- |
Homo sapiens | 3'-carbamoylbiphenyl-3-yl undec-10-yn-1-ylcarbamate | |
| 3.5.1.4 | 0.000001 | - |
- |
Homo sapiens | 3'-carbamoylbiphenyl-3-yl undec-10-yn-1-ylcarbamate | |
| 3.5.1.4 | 0.0000134 | - |
- |
Homo sapiens | 7-phenyl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one | |
| 3.5.1.4 | 0.000206 | - |
- |
Homo sapiens | 7-phenyl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one | |
| 3.5.1.4 | 0.000283 | - |
- |
Homo sapiens | 4-(benzyloxy)phenyl butylcarbamate | |
| 3.5.1.4 | 0.00136 | - |
- |
Homo sapiens | 4-(benzyloxy)phenyl butylcarbamate | |
| 3.5.1.99 | 0.00000038 | - |
pH 9.0, 37°C | Homo sapiens | 3'-carbamoylbiphenyl-3-yl undec-10-yn-1-ylcarbamate | |
| 3.5.1.99 | 0.000001 | - |
pH 9.0, 37°C | Homo sapiens | JP104 | |
| 3.5.1.99 | 0.0000134 | - |
pH 9.0, 37°C | Homo sapiens | OL-135 | |
| 3.5.1.99 | 0.000206 | - |
pH 9.0, 37°C | Homo sapiens | 7-phenyl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one | |
| 3.5.1.99 | 0.000283 | - |
pH 9.0, 37°C | Homo sapiens | 4-(benzyloxy)phenyl butylcarbamate | |
| 3.5.1.99 | 0.00136 | - |
pH 9.0, 37°C | Homo sapiens | URB532 | |
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