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Literature summary extracted from

  • Suzuki, T.; Hara, I.; Nakano, M.; Zhao, G.; Lennarz, W.J.; Schindelin, H.; Taniguchi, N.; Totani, K.; Matsuo, I.; Ito, Y.
    Site-specific labeling of cytoplasmic peptide:N-glycanase by N,N-diacetylchitobiose-related compounds (2006), J. Biol. Chem., 281, 22152-22160.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
3.5.1.52 C191A mutant enzyme does not bind to the inhibitor Man9GlcNAc2-iodoacetoamide Saccharomyces cerevisiae

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.52 Man8GlcNAc2-iodoacetoamide
-
 Saccharomyces cerevisiae
3.5.1.52 Man9GlcNAc2
-
 Saccharomyces cerevisiae
3.5.1.52 Man9GlcNAc2-iodoacetoamide strong inhibitor, irreversibly inhibits that catalytic Cys in a highly specific manner Saccharomyces cerevisiae
3.5.1.52 N,N'-diacetylchitobiosylbromoacetamide
-
 Saccharomyces cerevisiae
3.5.1.52 N,N'-diacetylchitobiosylchloroacetamide
-
 Saccharomyces cerevisiae
3.5.1.52 N,N'-diacetylchitobiosyliodoacetamide
-
 Saccharomyces cerevisiae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.5.1.52 cytoplasm
-
 Saccharomyces cerevisiae 5737
-

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.52 Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.5.1.52
-
 Saccharomyces cerevisiae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.52 RNase B + H2O
-
 Saccharomyces cerevisiae ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.1.52 peptide:N-glycanase
-
 Saccharomyces cerevisiae
3.5.1.52 PNGase
-
 Saccharomyces cerevisiae

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.5.1.52 0.0008
-
-
 Saccharomyces cerevisiae N,N'-diacetylchitobiosyliodoacetamide
3.5.1.52 0.0016
-
-
 Saccharomyces cerevisiae Man8GlcNAc2-iodoacetoamide
3.5.1.52 0.0017
-
-
 Saccharomyces cerevisiae Man9GlcNAc2-iodoacetoamide
3.5.1.52 0.0028
-
-
 Saccharomyces cerevisiae N,N'-diacetylchitobiosylbromoacetamide
3.5.1.52 0.019
-
-
 Saccharomyces cerevisiae N,N'-diacetylchitobiosylchloroacetamide
3.5.1.52 0.17
-
-
 Saccharomyces cerevisiae Man9GlcNAc2