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Literature summary extracted from

  • Neuzil, J.; Dyason, J.C.; Freeman, R.; Dong, L.F.; Prochazka, L.; Wang, X.F.; Scheffler, I.; Ralph, S.J.
    Mitocans as anti-cancer agents targeting mitochondria: lessons from studies with vitamin E analogues, inhibitors of complex II (2007), J. Bioenerg. Biomembr., 39, 65-72.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.5.1 alpha-tocopheryl succinate binds to the Qp site of the mitochondrial complex II causing the generation of superoxide triggering mitochondrial destabilisation and initiation of apoptotic pathways, mechanism, overview Bos taurus
1.3.5.1 vitamin E analogues epitomised by alpha-tocopheryl succinate affect the electron flow from complex II Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.5.1 mitochondrial membrane
-
 Bos taurus 31966
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.5.1 additional information Bos taurus vitamin E analogues bind to the Qp site of the mitochondrial complex II causing the generation of superoxide triggering mitochondrial destabilisation and initiation of apoptotic pathways, mechanism, overview ?
-
 ?
1.3.5.1 succinate + ubiquinone Bos taurus complex II is the only membrane bound enzyme of the Krebs cycle, and it feeds electrons into the electron transport chain from the oxidation of succinate fumarate + ubiquinol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.5.1 Bos taurus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.5.1 additional information vitamin E analogues bind to the Qp site of the mitochondrial complex II causing the generation of superoxide triggering mitochondrial destabilisation and initiation of apoptotic pathways, mechanism, overview Bos taurus ?
-
 ?
1.3.5.1 succinate + ubiquinone complex II is the only membrane bound enzyme of the Krebs cycle, and it feeds electrons into the electron transport chain from the oxidation of succinate Bos taurus fumarate + ubiquinol
-
 ?
1.3.5.1 succinate + ubiquinone electrons move from the FAD prosthetic group in SDH on to the two matrix subunits via a series of [Fe-S] redox clusters and possibly also via a heme group to end up at the terminal acceptor ubiquinone residing within the membrane subunits CybL and CybS Bos taurus fumarate + ubiquinol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.5.1 mitochondrial complex II
-
 Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.5.1 ubiquinone
-
 Bos taurus