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Literature summary extracted from

  • Vessey, D.A.; Kelley, M.; Zhang, J.; Li, L.; Tao, R.; Karliner, J.S.
    Dimethylsphingosine and FTY720 inhibit the SK1 form but activate the SK2 form of sphingosine kinase from rat heart (2007), J. Biochem. Mol. Toxicol., 21, 273-279.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.91 N,N-dimethylsphingosine 0.005 mM, activation to 106% of control Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.91 D,L-threo-dihydrosphingosine 0.005 mM, 64% inhibition Rattus norvegicus
2.7.1.91 DL-threo-dihydrosphingosine 0.005 mM, 25% inhibition Rattus norvegicus
2.7.1.91 FTY720 0.005 mM, 73% inhibition; 0.005 mM, 8% inhibition Rattus norvegicus
2.7.1.91 L-erythro-sphingosine 0.005 mM, 41% inhibition; 0.005 mM, 43% inhibition Rattus norvegicus
2.7.1.91 N,N-dimethylsphingosine 0.005 mM, 56% inhibition Rattus norvegicus
2.7.1.91 phytosphingosine 0.0025 mM, 21% inhibition; 0.0025 mM, 64% inhibition Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.91 cytosol
-
 Rattus norvegicus 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.1.91 45000
-
 x * 45000, SDS-PAGE Rattus norvegicus
2.7.1.91 96000
-
 x * 96000, SDS-PAGE Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.91 Rattus norvegicus Q6AYB2
-
-
2.7.1.91 Rattus norvegicus Q91V26
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.91 heart
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.91 ATP + sphingosine
-
 Rattus norvegicus ADP + sphingosine 1-phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.1.91 ? x * 45000, SDS-PAGE Rattus norvegicus
2.7.1.91 ? x * 96000, SDS-PAGE Rattus norvegicus

Synonyms

EC Number Synonyms Comment Organism
2.7.1.91 SK1
-
 Rattus norvegicus
2.7.1.91 SK2
-
 Rattus norvegicus
2.7.1.91 sphinganine kinase
-
 Rattus norvegicus
2.7.1.91 SPHK1
-
 Rattus norvegicus
2.7.1.91 SPHK2
-
 Rattus norvegicus