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Literature summary extracted from

  • Taniai, H.; Iida, K.; Seki, M.; Saito, M.; Shiota, S.; Nakayama, H.; Yoshida, S.
    Concerted action of lactate oxidase and pyruvate oxidase in aerobic growth of Streptococcus pneumoniae: role of lactate as an energy source (2008), J. Bacteriol., 190, 3572-3579.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
1.2.3.3 additional information aerobiosis makes the concerted action of lactate oxidase and pyruvate oxidase possible, enabling cells of Streptococcus pneumoniae to gain more ATP from glucose than under anaerobiosis Streptococcus pneumoniae

Protein Variants

EC Number Protein Variants Comment Organism
1.1.3.15 additional information in an enzyme disruption mutant, the highest concentration of H2O2 attained in the medium is found to be approximately 1 mM, about one-fifth the level for the parental strain. Although cell growth continuous until glucose in the medium becomes undetectable even in the absence of added catalase, the maximum cell mass attained is considerably higher in the presence of catalase than in its absence. The maximum cell mass achieved in the presence of added catalase is reproducibly lower by 0.2 to 0.3 turbidity units than that of the parent Streptococcus pneumoniae
1.2.3.3 additional information SpxB-deficient mutant, shows drastically diminished H2O2 production Streptococcus pneumoniae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.3.15 additional information Streptococcus pneumoniae energy-yielding metabolism can be described as follows: as long as glucose is available, approximatelyone-fourth of the pyruvate formed is converted to acetate by the sequential action of pyruvate oxidase and acetate kinase with acquisition of additional ATP. The rest of the pyruvate is reduced by lactate dehydrogenase to form lactate, with partial achievement of redox balance. The lactate is oxidized by lactate oxidase back to pyruvate, which is converted to acetate as described above; and the sequential reactions mentioned above continue to occur as long as lactate is present ?
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 ?
1.1.3.15 additional information Streptococcus pneumoniae GTC13809 energy-yielding metabolism can be described as follows: as long as glucose is available, approximatelyone-fourth of the pyruvate formed is converted to acetate by the sequential action of pyruvate oxidase and acetate kinase with acquisition of additional ATP. The rest of the pyruvate is reduced by lactate dehydrogenase to form lactate, with partial achievement of redox balance. The lactate is oxidized by lactate oxidase back to pyruvate, which is converted to acetate as described above; and the sequential reactions mentioned above continue to occur as long as lactate is present ?
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 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.3.15 Streptococcus pneumoniae
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 activities of both lactarte oxidase and pyruvate oxidase in wild-type cultures are detectable even in the early exponential phase of growth and attain the highest levels in the early stationary phase
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1.2.3.3 Streptococcus pneumoniae
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-
-
1.2.3.3 Streptococcus pneumoniae GTC13809
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.3.3 additional information enzyme activity detectable even in the early exponential phase of growth and attains the highest levels in the early stationary phase Streptococcus pneumoniae
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.3.15 additional information energy-yielding metabolism can be described as follows: as long as glucose is available, approximatelyone-fourth of the pyruvate formed is converted to acetate by the sequential action of pyruvate oxidase and acetate kinase with acquisition of additional ATP. The rest of the pyruvate is reduced by lactate dehydrogenase to form lactate, with partial achievement of redox balance. The lactate is oxidized by lactate oxidase back to pyruvate, which is converted to acetate as described above; and the sequential reactions mentioned above continue to occur as long as lactate is present Streptococcus pneumoniae ?
-
 ?
1.1.3.15 additional information energy-yielding metabolism can be described as follows: as long as glucose is available, approximatelyone-fourth of the pyruvate formed is converted to acetate by the sequential action of pyruvate oxidase and acetate kinase with acquisition of additional ATP. The rest of the pyruvate is reduced by lactate dehydrogenase to form lactate, with partial achievement of redox balance. The lactate is oxidized by lactate oxidase back to pyruvate, which is converted to acetate as described above; and the sequential reactions mentioned above continue to occur as long as lactate is present Streptococcus pneumoniae GTC13809 ?
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 ?
1.2.3.3 pyruvate + phosphate + O2
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 Streptococcus pneumoniae acetyl phosphate + CO2 + H2O2
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 ?
1.2.3.3 pyruvate + phosphate + O2
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 Streptococcus pneumoniae GTC13809 acetyl phosphate + CO2 + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.3.3 SpxB protein
-
 Streptococcus pneumoniae