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Literature summary extracted from

  • Niu, C.; Clemmer, K.M.; Bonomo, R.A.; Rather, P.N.
    Isolation and characterization of an autoinducer synthase from Acinetobacter baumannii (2008), J. Bacteriol., 190, 3386-3392.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.184 3-hydroxy-C12-HSL abaI is regulated by a positive-feedback loop involving self-produced acyl-homoserine lactone signals Acinetobacter baumannii

Application

EC Number Application Comment Organism
2.3.1.184 medicine Acinetobacter baumannii is an important nosocomial pathogen and can cause a variety of infections including wound infection, bloodstrem infection, ventilator-acquired pneumonia, and urinary tract infections Acinetobacter baumannii

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.184 the abaI gene is cloned into the pBluescript SK vector Acinetobacter baumannii

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.184 abaI_Km mutant mutant failed to produce any detectable acyl-homoserine lactone signals Acinetobacter baumannii

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.184 an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine Acinetobacter baumannii
-
 [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.184 Acinetobacter baumannii B0FLN1
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.184 an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine
-
 Acinetobacter baumannii [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.184 AbaI
-
 Acinetobacter baumannii
2.3.1.184 acyl-homoserine-lactone synthase
-
 Acinetobacter baumannii
2.3.1.184 AHL synthase
-
 Acinetobacter baumannii
2.3.1.184 autoinducer synthase
-
 Acinetobacter baumannii