Literature summary extracted from

Yang, L.; Lewis, C.M.; Chandrasekharan, U.M.; Kinney, C.M.; Dicorleto, P.E.; Kashyap, V.S.
Arginase activity is increased by thrombin: a mechanism for endothelial dysfunction in arterial thrombosis (2006), J. Am. Coll. Surg., 203, 817-826.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
3.5.3.1	additional information	fibrin has no effect on arginase activity	Homo sapiens
3.5.3.1	thrombin	endothelial cell exposition to 10 U/ml thrombin for 4 h leads to 1.6fold increased arginase activity	Homo sapiens
3.5.3.1	thrombin receptor antagonist peptide	endothelial cell exposition to 10 U/ml thrombin receptor antagonist peptide for 4 h leads to increased arginase activity	Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3.5.3.1	L-arginine + H2O	Homo sapiens	-	L-ornithine + urea	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.5.3.1	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.5.3.1	HUVEC cell	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.5.3.1	L-arginine + H2O	-	Homo sapiens	L-ornithine + urea	-	?

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Release 2023.1 (January 2023)