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Literature summary extracted from

  • Vanoni, M.A.; Curti, B.
    Structure-function studies of glutamate synthases: a class of self-regulated iron-sulfur flavoenzymes essential for nitrogen assimilation (2008), IUBMB Life, 60, 287-300.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.4.7.1 E1013A dramatically lowered activity Synechocystis sp.
1.4.7.1 E1013D dramatically lowered activity Synechocystis sp.
1.4.7.1 E1013N dramatically lowered activity Synechocystis sp.

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.7.1 6-diazo-5-oxo-L-norleucine
-
 Synechocystis sp.

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.4.7.1 Fe2+ iron-sulfur centre Synechocystis sp.

Organism

EC Number Organism UniProt Comment Textmining
1.4.1.14 Aedes aegypti
-
-
-
1.4.1.14 Anopheles gambiae
-
-
-
1.4.1.14 Bombyx mori
-
-
-
1.4.1.14 Caenorhabditis elegans
-
-
-
1.4.1.14 Ciona intestinalis
-
-
-
1.4.1.14 Drosophila melanogaster
-
-
-
1.4.1.14 Plasmodium falciparum
-
-
-
1.4.7.1 Synechocystis sp. P55038
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.1.14 L-glutamine + 2-oxoglutarate + NADH
-
 Drosophila melanogaster L-glutamate + NAD+
-
 ?
1.4.1.14 L-glutamine + 2-oxoglutarate + NADH
-
 Bombyx mori L-glutamate + NAD+
-
 ?
1.4.1.14 L-glutamine + 2-oxoglutarate + NADH
-
 Caenorhabditis elegans L-glutamate + NAD+
-
 ?
1.4.1.14 L-glutamine + 2-oxoglutarate + NADH
-
 Aedes aegypti L-glutamate + NAD+
-
 ?
1.4.1.14 L-glutamine + 2-oxoglutarate + NADH
-
 Plasmodium falciparum L-glutamate + NAD+
-
 ?
1.4.1.14 L-glutamine + 2-oxoglutarate + NADH
-
 Ciona intestinalis L-glutamate + NAD+
-
 ?
1.4.1.14 L-glutamine + 2-oxoglutarate + NADH
-
 Anopheles gambiae L-glutamate + NAD+
-
 ?
1.4.7.1 L-glutamine + 2-oxoglutarate + 2 reduced ferredoxin + 2 H+
-
 Synechocystis sp. 2 L-glutamate + 2 oxidized ferredoxin
-
 ?

Subunits

EC Number Subunits Comment Organism
1.4.7.1 monomer in solution Synechocystis sp.

Synonyms

EC Number Synonyms Comment Organism
1.4.1.14 NADH-dependent glutamate synthase
-
 Drosophila melanogaster
1.4.1.14 NADH-dependent glutamate synthase
-
 Bombyx mori
1.4.1.14 NADH-dependent glutamate synthase
-
 Caenorhabditis elegans
1.4.1.14 NADH-dependent glutamate synthase
-
 Aedes aegypti
1.4.1.14 NADH-dependent glutamate synthase
-
 Plasmodium falciparum
1.4.1.14 NADH-dependent glutamate synthase
-
 Ciona intestinalis
1.4.1.14 NADH-dependent glutamate synthase
-
 Anopheles gambiae
1.4.1.14 NADH-GltS
-
 Drosophila melanogaster
1.4.1.14 NADH-GltS
-
 Bombyx mori
1.4.1.14 NADH-GltS
-
 Caenorhabditis elegans
1.4.1.14 NADH-GltS
-
 Aedes aegypti
1.4.1.14 NADH-GltS
-
 Plasmodium falciparum
1.4.1.14 NADH-GltS
-
 Ciona intestinalis
1.4.1.14 NADH-GltS
-
 Anopheles gambiae
1.4.7.1 glutamate synthase
-
 Synechocystis sp.

Cofactor

EC Number Cofactor Comment Organism Structure
1.4.1.14 NADH
-
 Drosophila melanogaster
1.4.1.14 NADH
-
 Bombyx mori
1.4.1.14 NADH
-
 Caenorhabditis elegans
1.4.1.14 NADH
-
 Aedes aegypti
1.4.1.14 NADH
-
 Plasmodium falciparum
1.4.1.14 NADH
-
 Ciona intestinalis
1.4.1.14 NADH
-
 Anopheles gambiae
1.4.7.1 FMN
-
 Synechocystis sp.
1.4.7.1 iron-sulfur centre
-
 Synechocystis sp.