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Literature summary extracted from

  • Wang, H.W.; Lin, C.P.; Chiu, J.H.; Chow, K.C.; Kuo, K.T.; Lin, C.S.; Wang, L.S.
    Reversal of inflammation-associated dihydrodiol dehydrogenases (AKR1C1 and AKR1C2) overexpression and drug resistance in nonsmall cell lung cancer cells by wogonin and chrysin (2007), Int. J. Cancer, 120, 2019-2027.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.3.1.20 interleukin-6 stimulates enzyme expression Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.20 chrysin inhibits enzyme expression at concentrations higher than 0.01 mM; inhibits enzyme expression at concentrations higher than 0.01 mM Homo sapiens
1.3.1.20 additional information enzyme expression is not inhibited by baicalin and baicalein; enzyme expression is not inhibited by baicalin and baicalein Homo sapiens
1.3.1.20 wogonin inhibits enzyme expression at concentrations higher than 0.0025 mM; inhibits enzyme expression at concentrations higher than 0.0025 mM Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.3.1.20 34000
-
 SDS-PAGE Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.20 Homo sapiens P52895 aldo-keto reductase family 1 member C2, AKR1C2
-
1.3.1.20 Homo sapiens Q04828 aldo-keto reductase family 1 member C1, AKR1C1
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.20 non-small cell lung cancer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.20 trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+
-
 Homo sapiens catechol + NAD(P)H
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.20 AKR1C1
-
 Homo sapiens
1.3.1.20 AKR1C2
-
 Homo sapiens
1.3.1.20 DDH member of the aldo-keto reductases superfamily which plays a central role in the metabolism of steroid hormones, prostaglandins and xenobiotics Homo sapiens
1.3.1.20 dihydrodiol dehydrogenase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.20 NAD(P)+
-
 Homo sapiens