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Literature summary extracted from

  • Song, X.H.; Liang, B.; Liu, G.F.; Li, R.; Xie, J.P.; Du, K.; Huang, D.Y.
    Expression of a novel alternatively spliced variant of NADP(H)-dependent retinol dehydrogenase/reductase with deletion of exon 3 in cervical squamous carcinoma (2007), Int. J. Cancer, 120, 1618-1626.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.300 expressed in native, soluble form in Escherichia coli BL21-AI and as GFP-fusion protein in HeLa-cells Homo sapiens
1.1.1.300 GFP-fusion protein in HeLa-cells Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.300 additional information not detected in the peroxisome Homo sapiens
-
-
1.1.1.300 peroxisome
-
 Homo sapiens 5777
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.300 23917
-
 x * 23917, calculated from the deduced amino acid sequence Homo sapiens
1.1.1.300 27572
-
 x * 27572, calculated from the deduced amino acid sequence Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.300 retinol + NADP+ Homo sapiens important for the maintenance of retinoid homeostasis retinal + NADPH + H+
-
 r
1.1.1.300 retinol + NADP+ Homo sapiens important for the maintenance of retinoid homeostasis, low activity of the NRDRB1 splice variant possibly contributes to a disturbed retinoid homeostasis leading to abnormal differentiation and high susceptibility to human papilloma virus in the cervical epithelium retinal + NADPH + H+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.300 Homo sapiens Q9BTZ2
-
-
1.1.1.300 Homo sapiens Q9BTZ2 isoform 6, from full length cDNA, isoform of NRDR without residues 1-203; alternatively spliced variant NRDRA1 with a complete deletion of exons 3-6
-
1.1.1.300 Homo sapiens Q9BTZ2 isoform 4, from full length cDNA, isoform of NRDR without residues 85-118; alternatively spliced variant NRDRB1 with a complete deletion of exon 3, activity of NRDRB1 much lower than activity of NRDR in forward and reverse reaction
-
1.1.1.300 Homo sapiens Q9BTZ2 isoform 5, from full length cDNA, isoform of NRDR without residues 85-118 and 160-204; alternatively spliced variant NRDRB2 with a complete deletion of exons 3 and 6
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.300 recombinant protein from Escherichia coli Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.300 cervix detected in 54% of cervical tumor tissue samples but not in normal cervical tissue Homo sapiens
-
1.1.1.300 cervix detected in cervical tumor tissue samples where NRDRB1 could not be detected Homo sapiens
-
1.1.1.300 cervix normal and neoplastic cervical tissue samples Homo sapiens
-
1.1.1.300 HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.300 retinol + NADP+ important for the maintenance of retinoid homeostasis Homo sapiens retinal + NADPH + H+
-
 r
1.1.1.300 retinol + NADP+ important for the maintenance of retinoid homeostasis, low activity of the NRDRB1 splice variant possibly contributes to a disturbed retinoid homeostasis leading to abnormal differentiation and high susceptibility to human papilloma virus in the cervical epithelium Homo sapiens retinal + NADPH + H+
-
 r

Subunits

EC Number Subunits Comment Organism
1.1.1.300 ? x * 23917, calculated from the deduced amino acid sequence Homo sapiens
1.1.1.300 ? x * 27572, calculated from the deduced amino acid sequence Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
1.1.1.300 More enzyme additionally displays high aldehyde reductase activity in retinoic acid metabolism Homo sapiens
1.1.1.300 NADP(H)-dependent retinol dehydrogenase/reductase
-
 Homo sapiens
1.1.1.300 NRDR
-
 Homo sapiens
1.1.1.300 NRDRA1 alternatively spliced variant with a complete deletion of exons 3-6 Homo sapiens
1.1.1.300 NRDRB1 alternatively spliced variant with a complete deletion of exon 3 Homo sapiens
1.1.1.300 NRDRB2 alternatively spliced variant with a complete deletion of exons 3 and 6 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.300 NADP+
-
 Homo sapiens
1.1.1.300 NADPH
-
 Homo sapiens

pI Value

EC Number Organism Comment pI Value Maximum pI Value
1.1.1.300 Homo sapiens calculated from the deduced amino acid sequence
-
 7.67
1.1.1.300 Homo sapiens calculated from the deduced amino acid sequence
-
 9.32