EC Number | Cloned (Comment) | Organism |
---|---|---|
1.1.1.300 | expressed in native, soluble form in Escherichia coli BL21-AI and as GFP-fusion protein in HeLa-cells | Homo sapiens |
1.1.1.300 | GFP-fusion protein in HeLa-cells | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.1.1.300 | additional information | not detected in the peroxisome | Homo sapiens | - |
- |
1.1.1.300 | peroxisome | - |
Homo sapiens | 5777 | - |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.1.1.300 | 23917 | - |
x * 23917, calculated from the deduced amino acid sequence | Homo sapiens |
1.1.1.300 | 27572 | - |
x * 27572, calculated from the deduced amino acid sequence | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.300 | retinol + NADP+ | Homo sapiens | important for the maintenance of retinoid homeostasis | retinal + NADPH + H+ | - |
r | |
1.1.1.300 | retinol + NADP+ | Homo sapiens | important for the maintenance of retinoid homeostasis, low activity of the NRDRB1 splice variant possibly contributes to a disturbed retinoid homeostasis leading to abnormal differentiation and high susceptibility to human papilloma virus in the cervical epithelium | retinal + NADPH + H+ | - |
r |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.300 | Homo sapiens | Q9BTZ2 | - |
- |
1.1.1.300 | Homo sapiens | Q9BTZ2 | isoform 6, from full length cDNA, isoform of NRDR without residues 1-203; alternatively spliced variant NRDRA1 with a complete deletion of exons 3-6 | - |
1.1.1.300 | Homo sapiens | Q9BTZ2 | isoform 4, from full length cDNA, isoform of NRDR without residues 85-118; alternatively spliced variant NRDRB1 with a complete deletion of exon 3, activity of NRDRB1 much lower than activity of NRDR in forward and reverse reaction | - |
1.1.1.300 | Homo sapiens | Q9BTZ2 | isoform 5, from full length cDNA, isoform of NRDR without residues 85-118 and 160-204; alternatively spliced variant NRDRB2 with a complete deletion of exons 3 and 6 | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.1.1.300 | recombinant protein from Escherichia coli | Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.1.1.300 | cervix | detected in 54% of cervical tumor tissue samples but not in normal cervical tissue | Homo sapiens | - |
1.1.1.300 | cervix | detected in cervical tumor tissue samples where NRDRB1 could not be detected | Homo sapiens | - |
1.1.1.300 | cervix | normal and neoplastic cervical tissue samples | Homo sapiens | - |
1.1.1.300 | HeLa cell | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.300 | retinol + NADP+ | important for the maintenance of retinoid homeostasis | Homo sapiens | retinal + NADPH + H+ | - |
r | |
1.1.1.300 | retinol + NADP+ | important for the maintenance of retinoid homeostasis, low activity of the NRDRB1 splice variant possibly contributes to a disturbed retinoid homeostasis leading to abnormal differentiation and high susceptibility to human papilloma virus in the cervical epithelium | Homo sapiens | retinal + NADPH + H+ | - |
r |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.1.1.300 | ? | x * 23917, calculated from the deduced amino acid sequence | Homo sapiens |
1.1.1.300 | ? | x * 27572, calculated from the deduced amino acid sequence | Homo sapiens |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.1.1.300 | More | enzyme additionally displays high aldehyde reductase activity in retinoic acid metabolism | Homo sapiens |
1.1.1.300 | NADP(H)-dependent retinol dehydrogenase/reductase | - |
Homo sapiens |
1.1.1.300 | NRDR | - |
Homo sapiens |
1.1.1.300 | NRDRA1 | alternatively spliced variant with a complete deletion of exons 3-6 | Homo sapiens |
1.1.1.300 | NRDRB1 | alternatively spliced variant with a complete deletion of exon 3 | Homo sapiens |
1.1.1.300 | NRDRB2 | alternatively spliced variant with a complete deletion of exons 3 and 6 | Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.300 | NADP+ | - |
Homo sapiens | |
1.1.1.300 | NADPH | - |
Homo sapiens |
EC Number | Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|---|
1.1.1.300 | Homo sapiens | calculated from the deduced amino acid sequence | - |
7.67 |
1.1.1.300 | Homo sapiens | calculated from the deduced amino acid sequence | - |
9.32 |