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Literature summary extracted from

  • Yang, X.; Zhang, Z.; Jia, S.; Liu, Y.; Wang, X.; Yan, Q.
    Overexpression of fucosyltransferase IV in A431 cell line increases cell proliferation (2007), Int. J. Biochem. Cell Biol., 39, 1722-1730.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.4.1.152 medicine fucosyltransferase IV overexpression promotes cell proliferation, increases the expression of proliferating cell nuclear antigen and augments Lewis Y expression to trigger neoplastic cell proliferation, fucosyltransferase IV may serve as a potential therapeutic target for the treatment of Lewis Y-positive epithelial cancers Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.152 overexpression in A-431 cells cells, two stable FUT-4 cell lines A431-FUT4-1 and A431-FUT4-2 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.152 Homo sapiens P22083
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-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.152 uterus
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.152 GDP-fucose + Fucalpha1-2Galbeta1-4GlcNAcbeta1-R
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 Homo sapiens GDP + Fucalpha1-2Galbeta1-4(Fucalpha1-3)GlcNAcbeta1-R Lewis Y antigen, increased expression in cancer cells ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.152 fucosyltransferase IV
-
 Homo sapiens