EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.6.3.1 | bilirubin | bilirubin concentration-dependently reduces NADPH oxidase-dependent superoxide production stimulated by phorbol 12-myristate 13-acetate | Homo sapiens | |
1.6.3.1 | bilirubin | bilirubin concentration-dependently reduces NADPH oxidase-dependent superoxide production stimulated by angiotensin II in vascular smooth muscle cells | Rattus norvegicus | |
1.6.3.1 | hemin | hemin treatment increases hemin oxidase-1 expression and activity in aorta and kidney of apolipoprotein Edeficient mice and significantly reduces both NADPH oxidase activity and superoxide generation in situ | Mus musculus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.6.3.1 | Homo sapiens | - |
- |
- |
1.6.3.1 | Mus musculus | - |
apolipoprotein E-deficient mice, which display vascular oxidative stress | - |
1.6.3.1 | Rattus norvegicus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.6.3.1 | aorta | hemin treatment increases hemin oxidase-1 expression and activity in aorta and kidney of apolipoprotein E-deficient mice and significantly reduces both NADPH oxidase activity and superoxide generation in situ. Effects are reversed by tin protoporphyrin-IX and are not associated with changes in isoforms Nox2 or Nox4 protein levels. Inhibition of NADPH oxidase activity by hemin in the aorta is mimicked by bilirubin in vitro | Mus musculus | - |
1.6.3.1 | HL-60 cell | bilirubin concentration-dependently reduces NADPH oxidase-dependent superoxide production stimulated by phorbol 12-myristate 13-acetate | Homo sapiens | - |
1.6.3.1 | kidney | hemin treatment increases hemin oxidase-1 expression and activity in aorta and kidney of apolipoprotein E-deficient mice and significantly reduces both NADPH oxidase activity and superoxide generation in situ. Effects are reversed by tin protoporphyrin-IX and are not associated with changes in isoforms Nox2 or Nox4 protein levels | Mus musculus | - |
1.6.3.1 | smooth muscle | bilirubin concentration-dependently reduces NADPH oxidase-dependent superoxide production stimulated by angiotensin II in vascular smooth muscle cells | Rattus norvegicus | - |