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Literature summary extracted from

  • Arias, D.G.; Carranza, P.G.; Lujan, H.D.; Iglesias, A.A.; Guerrero, S.A.
    Immunolocalization and enzymatic functional characterization of the thioredoxin system in Entamoeba histolytica (2008), Free Radic. Biol. Med., 45, 32-39.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.8.1.9 0.0028
-
 thioredoxin disulfide 8 pH 7, 30°C Entamoeba histolytica
1.8.1.9 0.0036
-
 thioredoxin disulfide 41 pH 7, 30°C Entamoeba histolytica

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.8.1.9 plasma membrane
-
 Entamoeba histolytica 5886
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.8.1.9 thioredoxin disulfide + NADPH + H+ Entamoeba histolytica the tandem system involving thioredoxin reductase and thioredoxin proves to be operative for reducing low molecular weight disulfides, including putative physiological substrates as cystine and oxidized trypanothione thioredoxin + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.9 Entamoeba histolytica
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.9 thioredoxin disulfide + NADPH + H+ the tandem system involving thioredoxin reductase and thioredoxin proves to be operative for reducing low molecular weight disulfides, including putative physiological substrates as cystine and oxidized trypanothione Entamoeba histolytica thioredoxin + NADP+
-
 ?
1.8.1.9 thioredoxin disulfide 41 + NADPH + H+
-
 Entamoeba histolytica thioredoxin 41 + NADP+
-
 ?
1.8.1.9 thioredoxin disulfide 8 + NADPH + H+
-
 Entamoeba histolytica thioredoxin 8 + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.1.9 EhTRXR
-
 Entamoeba histolytica

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.8.1.9 1.43
-
 thioredoxin disulfide 8 pH 7, 30°C Entamoeba histolytica
1.8.1.9 2.2
-
 thioredoxin disulfide 41 pH 7, 30°C Entamoeba histolytica

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.1.9 NADPH
-
 Entamoeba histolytica