Literature summary extracted from

Liu, F.; Hindupur, J.; Nguyen, J.L.; Ruf, K.J.; Zhu, J.; Schieler, J.L.; Bonham, C.C.; Wood, K.V.; Davisson, V.J.; Rochet, J.C.
Methionine sulfoxide reductase A protects dopaminergic cells from Parkinsons disease-related insults (2008), Free Radic. Biol. Med., 45, 242-255.

Application

EC Number	Application	Comment	Organism
1.8.4.11	medicine	MsrA efficiently reduces oxidized methionine residues in recombinant alpha-synuclein. Enhancing MsrA function may be a reasonable therapeutic strategy in Parkinson's disease	Bos taurus

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.8.4.11	peptide-L-methionine (S)-S-oxide + thioredoxin	Bos taurus	MsrA suppresses dopaminergic cell death and protein aggregation induced by the complex I inhibitor rotenone or mutant alpha-synuclein, but not by the proteasome inhibitor MG132. MsrA protects against Parkinson's disease-related stresses primarily via methionine sulfoxide repair rather than by scavenging reactive oxygen species	peptide-L-methionine + thioredoxin disulfide + H2O	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.8.4.11	Bos taurus	P54149	recombinant	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
1.8.4.11	-	Bos taurus

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.8.4.11	alpha-synuclein-L-methionine (S)-S-oxide + thioredoxin	-	Bos taurus	alpha-synuclein-L-methionine + thioredoxin disulfide + H2O	-	?
1.8.4.11	peptide-L-methionine (S)-S-oxide + thioredoxin	MsrA suppresses dopaminergic cell death and protein aggregation induced by the complex I inhibitor rotenone or mutant alpha-synuclein, but not by the proteasome inhibitor MG132. MsrA protects against Parkinson's disease-related stresses primarily via methionine sulfoxide repair rather than by scavenging reactive oxygen species	Bos taurus	peptide-L-methionine + thioredoxin disulfide + H2O	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
1.8.4.11	methionine sulfoxide reductase A	-	Bos taurus
1.8.4.11	MsrA	-	Bos taurus

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Release 2023.1 (January 2023)