Literature summary extracted from

Lin, Q.S.; Weis, S.; Yang, G.; Zhuang, T.; Abate, A.; Dennery, P.A.
Catalytic inactive heme oxygenase-1 protein regulates its own expression in oxidative stress (2008), Free Radic. Biol. Med., 44, 847-855.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
1.14.14.18	additional information	HO-1 is inducible in response to a variety of chemical and physical stress conditions to function as a cytoprotective molecule, hemin and cadmium chloride-mediated HO-1 induction, overview	Rattus norvegicus

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
1.14.14.18	expression of GST-tagged wild-type and mutant enzymes in Escherichia coli strain BL21(DE3), transfection of wild-type HO-1 cDNA or intracellular delivery of pure HO-1 protein into cultured NIH 3T3 cells results in activation of a 15-kb HO-1 promoter independently of HO activity, expression of an catalytically inactive HO-1 also results in promoter activation, HO-1-mediated promoter activation is regulated via the distal enhancers E1 and E2	Rattus norvegicus

Protein Variants

EC Number	Protein Variants	Comment	Organism
1.14.14.18	additional information	HO-1-specific siRNA significantly reduces hemin and cadmium chloride-mediated HO-1 induction, cobstruction of HO-1 deletion mutants showing decreased enzyme activity	Rattus norvegicus

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.14.14.18	tin protoporphyrin	SnPP	Rattus norvegicus

Molecular Weight [Da]

EC Number	Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
1.14.14.18	32000	-	x * 32000, SDS-PAGE	Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.14.14.18	heme + AH2 + O2	Rattus norvegicus	heme oxygenase is the rate-limiting enzyme in heme degradation to biliverdin, heme oxygenase-1 catalyzes the degradation of heme and forms antioxidant bile pigments as well as the signaling molecule carbon monoxide, HO-1 is inducible in response to a variety of chemical and physical stress conditions to function as a cytoprotective molecule. Catalytic inactive heme oxygenase-1 deletion mutant protein regulates its own expression in oxidative stress in a positive feedback manner, feed-forward autoregulation of HO-1 in oxidative stress, overview, HO-1 protein also plays a role in regulating cadmium chloride-mediated HO-1 gene induction	biliverdin + Fe2+ + CO + A + H2O	-	?
1.14.14.18	additional information	Rattus norvegicus	HO-1 regulation, HO-1 autoregulation, and HO-1 regulatory functions, activation of MAPK pathways is not required in HO-1 self-regulation, overview	?	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.14.14.18	Rattus norvegicus	P06762	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.14.14.18	heme + AH2 + O2	-	Rattus norvegicus	biliverdin + Fe2+ + CO + A + H2O	-	?
1.14.14.18	heme + AH2 + O2	heme oxygenase is the rate-limiting enzyme in heme degradation to biliverdin, heme oxygenase-1 catalyzes the degradation of heme and forms antioxidant bile pigments as well as the signaling molecule carbon monoxide, HO-1 is inducible in response to a variety of chemical and physical stress conditions to function as a cytoprotective molecule. Catalytic inactive heme oxygenase-1 deletion mutant protein regulates its own expression in oxidative stress in a positive feedback manner, feed-forward autoregulation of HO-1 in oxidative stress, overview, HO-1 protein also plays a role in regulating cadmium chloride-mediated HO-1 gene induction	Rattus norvegicus	biliverdin + Fe2+ + CO + A + H2O	-	?
1.14.14.18	additional information	HO-1 regulation, HO-1 autoregulation, and HO-1 regulatory functions, activation of MAPK pathways is not required in HO-1 self-regulation, overview	Rattus norvegicus	?	-	?

Subunits

EC Number	Subunits	Comment	Organism
1.14.14.18	?	x * 32000, SDS-PAGE	Rattus norvegicus

Synonyms

EC Number	Synonyms	Comment	Organism
1.14.14.18	heme oxygenase-1	-	Rattus norvegicus
1.14.14.18	HO-1	-	Rattus norvegicus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)