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Literature summary extracted from

  • Bishop, G.M.; Dringen, R.; Robinson, S.R.
    Zinc stimulates the production of toxic reactive oxygen species (ROS) and inhibits glutathione reductase in astrocytes (2007), Free Radic. Biol. Med., 42, 1222-1230.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.1.7 carmustine
-
 Rattus norvegicus
1.8.1.7 Zn2+ Zn acetate at concentrations of 0.1 mM or greater inactivate glutathione reductase via an NADPH-dependent mechanism. Zn2+ is a highly effective inhibitor of glutathione reductase activity in astrocytes. This inhibition impairs their capacity to detoxify H2O2 Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.7 Rattus norvegicus
-
 Wistar
-
1.8.1.7 Rattus norvegicus Wistar
-
 Wistar
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.1.7 astrocyte
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.7 GSSG + NADPH + H+
-
 Rattus norvegicus glutathione + NADP+
-
 ?
1.8.1.7 GSSG + NADPH + H+
-
 Rattus norvegicus Wistar glutathione + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.1.7 glutathione reductase
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.1.7 NADPH
-
 Rattus norvegicus