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Literature summary extracted from
- The inhibitory effect of tannic acid on cytochrome P450 enzymes and NADPH-CYP reductase in rat and human liver microsomes (2008), Food Chem. Toxicol., 46, 645-653.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.6.2.4 | Tannic acid | - |
Homo sapiens |  |
| 1.6.2.4 | Tannic acid | - |
Rattus norvegicus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.6.2.4 | microsome | - |
Homo sapiens | - |
- |
| 1.6.2.4 | microsome | - |
Rattus norvegicus | - |
- |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.6.2.4 | Homo sapiens | - |
- |
- |
| 1.6.2.4 | Rattus norvegicus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.6.2.4 | liver | - |
Homo sapiens | - |
| 1.6.2.4 | liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.6.2.4 | 2 ferricytochrome P450 + NADPH | - |
Homo sapiens | 2 ferrocytochrome P450 + NADP+ + H+ | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.6.2.4 | NADPH-CYP reductase | - |
Homo sapiens |
| 1.6.2.4 | NADPH-CYP reductase | - |
Rattus norvegicus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.6.2.4 | NADPH | - |
Homo sapiens | |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 1.6.2.4 | 0.0118 | - |
- |
Rattus norvegicus | Tannic acid | |
| 1.6.2.4 | 0.0174 | - |
- |
Homo sapiens | Tannic acid | |
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Release 2023.1 (January 2023)
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