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Literature summary extracted from

  • Hauser, M.; Horn, P.; Tournu, H.; Hauser, N.C.; Hoheisel, J.D.; Brown, A.J.; Dickinson, J.R.
    A transcriptome analysis of isoamyl alcohol-induced filamentation in yeast reveals a novel role for Gre2p as isovaleraldehyde reductase (2007), FEMS Yeast Res., 7, 84-92.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.1.1.265 additional information creation of a knockout mutant that forms large, invasive filaments Saccharomyces cerevisiae
1.1.1.283 additional information creation of a knockout mutant that forms large, invasive filaments Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.265 isovaleraldehyde + NADPH + H+ Saccharomyces cerevisiae important role in the suppression of filamentation in response to isoamyl alcohol/isovaleraldehyde isoamyl alcohol + NADP+
-
 r
1.1.1.283 additional information Saccharomyces cerevisiae important role in the suppression of filamentation in response to isoamyl alcohol ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.265 Saccharomyces cerevisiae
-
 wild type strains IWD72 and BY4741 and enzyme knockout mutants, knockout mutant forms large, invasive filaments, activity increases at 5-6 h of cultivation in the presence of 0.5% isoamyl alcohol and then quickly declines to become undetectable after 8 h
-
1.1.1.283 Saccharomyces cerevisiae
-
 wild type strains IWD72 and BY4741 and enzyme knockout mutants, knockout mutant forms large, invasive filaments, activity increases at 5-6 h of cultivation in the presence of 0.5% isoamyl alcohol and then quickly declines to become undetectable after 8 h
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.265 isovaleraldehyde + NADPH + H+ important role in the suppression of filamentation in response to isoamyl alcohol/isovaleraldehyde Saccharomyces cerevisiae isoamyl alcohol + NADP+
-
 r
1.1.1.265 additional information enzyme displays also NADPH dependent methylglyoxal reductase activity (EC 1.1.1.283) Saccharomyces cerevisiae ?
-
 ?
1.1.1.283 methylglyoxal + NADPH + H+
-
 Saccharomyces cerevisiae lactaldehyde + NADP+
-
 ?
1.1.1.283 additional information important role in the suppression of filamentation in response to isoamyl alcohol Saccharomyces cerevisiae ?
-
 ?
1.1.1.283 additional information enzyme displays also isovaleraldehyde reductase activity (EC 1.1.1.265) Saccharomyces cerevisiae ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.265 GRE2 gene product
-
 Saccharomyces cerevisiae
1.1.1.265 Gre2p
-
 Saccharomyces cerevisiae
1.1.1.265 isovaleraldehyde reductase
-
 Saccharomyces cerevisiae
1.1.1.265 More enzyme displays also NADPH dependent methylglyoxal reductase activity (EC 1.1.1.283) Saccharomyces cerevisiae
1.1.1.265 YOL151w gene product
-
 Saccharomyces cerevisiae
1.1.1.283 D-lactaldehyde dehydrogenase for the reverse reaction Saccharomyces cerevisiae
1.1.1.283 GRE2 gene product
-
 Saccharomyces cerevisiae
1.1.1.283 Gre2p
-
 Saccharomyces cerevisiae
1.1.1.283 methylglyoxal reductase
-
 Saccharomyces cerevisiae
1.1.1.283 methylglyoxal reductase (NADPH dependent)
-
 Saccharomyces cerevisiae
1.1.1.283 More enzyme displays also isovaleraldehyde reductase activity (EC 1.1.1.265) Saccharomyces cerevisiae
1.1.1.283 YOL151w gene product
-
 Saccharomyces cerevisiae

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.265 NADP+
-
 Saccharomyces cerevisiae
1.1.1.265 NADPH
-
 Saccharomyces cerevisiae
1.1.1.283 NADPH
-
 Saccharomyces cerevisiae