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Literature summary extracted from

  • Spry, C.; Kirk, K.; Saliba, K.J.
    Coenzyme A biosynthesis: an antimicrobial drug target (2008), FEMS Microbiol. Rev., 32, 56-106.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.33
-
 Staphylococcus aureus
2.7.1.33
-
 Mycobacterium tuberculosis

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.7.1.33
-
 Escherichia coli
2.7.1.33
-
 Mycobacterium tuberculosis

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.33 CoA competitive Escherichia coli
2.7.1.33 additional information inhibition by CoA thioesters Escherichia coli

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.33 0.027
-
 ATP
-
 Staphylococcus aureus
2.7.1.33 0.093
-
 pantothenate
-
 Staphylococcus aureus
2.7.1.33 0.136
-
 pantothenate
-
 Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.33 ATP + pantothenate Escherichia coli first step of the pathway from pantothenate to CoA. The activity of this protein is tightly regulated by CoA feedback inhibition, both in vitro and in vivo ADP + (R)-4'-phosphopantothenate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.33 Escherichia coli
-
-
-
2.7.1.33 Mycobacterium tuberculosis
-
-
-
2.7.1.33 Staphylococcus aureus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.33
-
 Staphylococcus aureus
2.7.1.33
-
 Mycobacterium tuberculosis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.33 ATP + pantothenate
-
 Staphylococcus aureus ADP + (R)-4'-phosphopantothenate
-
 ?
2.7.1.33 ATP + pantothenate
-
 Escherichia coli ADP + (R)-4'-phosphopantothenate
-
 ?
2.7.1.33 ATP + pantothenate
-
 Mycobacterium tuberculosis ADP + (R)-4'-phosphopantothenate
-
 ?
2.7.1.33 ATP + pantothenate first step of the pathway from pantothenate to CoA. The activity of this protein is tightly regulated by CoA feedback inhibition, both in vitro and in vivo Escherichia coli ADP + (R)-4'-phosphopantothenate
-
 ?
2.7.1.33 ATP + pantothenate
-
 Mycobacterium tuberculosis ADP + D-4'-phosphopantothenate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.33 CoaA
-
 Staphylococcus aureus
2.7.1.33 CoaA
-
 Escherichia coli
2.7.1.33 CoaA
-
 Mycobacterium tuberculosis
2.7.1.33 PanK
-
 Staphylococcus aureus
2.7.1.33 PanK
-
 Escherichia coli
2.7.1.33 PanK
-
 Mycobacterium tuberculosis