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Literature summary extracted from

  • Jacobsen, S.M.; Lane, M.C.; Harro, J.M.; Shirtliff, M.E.; Mobley, H.L.
    The high-affinity phosphate transporter Pst is a virulence factor for Proteus mirabilis during complicated urinary tract infection (2008), FEMS Immunol. Med. Microbiol., 52, 180-193.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
7.3.2.1 DNA and amino acid sequence determination of the pst operon, genes pstS and pstA expression is regulated by the two-component regulatory system PhoBR and is repressed until times of phosphate starvation Proteus mirabilis

Protein Variants

EC Number Protein Variants Comment Organism
7.3.2.1 additional information the normal suppression of enzyme expression by the two-component regulatory system PhoBR is relieved in pstS-Tn5 and pstA-Tn5 mutants, which constitutively produce AP regardless of growth conditions, pst mutants show no significant growth defects during the independent culture or coculture studies in rich medium, phosphate-limiting minimal salts medium, or human urine. Mutants complemented with the complete pst operon repress AP synthesis in vitro and colonize the mouse bladder in numbers comparable to the wild-type strain HI4320, overview Proteus mirabilis

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.3.2.1 additional information genes pstS and pstA expression is regulated by the two-component regulatory system PhoBR and is repressed until times of phosphate starvation Proteus mirabilis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.3.2.1 inner membrane PstA, a inner membrane permease Proteus mirabilis
-
-
7.3.2.1 periplasm PstS, periplasmic phosphate binding protein Proteus mirabilis
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.3.2.1 ATP + H2O + phosphate/out Proteus mirabilis
-
 ADP + phosphate + phosphate/in
-
 ?
7.3.2.1 ATP + H2O + phosphate/out Proteus mirabilis HI4320
-
 ADP + phosphate + phosphate/in
-
 ?
7.3.2.1 additional information Proteus mirabilis the high-affinity phosphate transporter Pst is a virulence factor for Proteus mirabilis during complicated urinary tract infection, overview ?
-
 ?
7.3.2.1 additional information Proteus mirabilis HI4320 the high-affinity phosphate transporter Pst is a virulence factor for Proteus mirabilis during complicated urinary tract infection, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.3.2.1 Proteus mirabilis
-
 the enzyme is encoded by genes pstS and pstA of the pst operon, pstSCAB-phoU
-
7.3.2.1 Proteus mirabilis HI4320
-
 the enzyme is encoded by genes pstS and pstA of the pst operon, pstSCAB-phoU
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.3.2.1 ATP + H2O + phosphate/out
-
 Proteus mirabilis ADP + phosphate + phosphate/in
-
 ?
7.3.2.1 ATP + H2O + phosphate/out
-
 Proteus mirabilis HI4320 ADP + phosphate + phosphate/in
-
 ?
7.3.2.1 additional information the high-affinity phosphate transporter Pst is a virulence factor for Proteus mirabilis during complicated urinary tract infection, overview Proteus mirabilis ?
-
 ?
7.3.2.1 additional information the high-affinity phosphate transporter Pst is a virulence factor for Proteus mirabilis during complicated urinary tract infection, overview Proteus mirabilis HI4320 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.3.2.1 high-affinity phosphate transporter
-
 Proteus mirabilis
7.3.2.1 Pst
-
 Proteus mirabilis