Literature summary extracted from

Herve-Grepinet, V.; Veillard, F.; Godat, E.; Heuze-Vourch, N.; Lecaille, F.; Lalmanach, G.
Extracellular catalase activity protects cysteine cathepsins from inactivation by hydrogen peroxide (2008), FEBS Lett., 582, 1307-1312.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
1.11.1.6	additional information	addition of non-toxic concentrations of H2O2 to cultured THP-1 cells neither influences catalase activity nor mRNA expression levels and activity of cathepsins	Homo sapiens

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.11.1.6	3-Amino-1,2,4-triazole	inhibitory. Inhibition of extracellular catalase activity leads to a striking inactivation of secreted cysteine cathepsins	Homo sapiens
1.11.1.6	KCN	inhibitory. Inhibition of extracellular catalase activity leads to a striking inactivation of secreted cysteine cathepsins	Homo sapiens

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
1.11.1.6	extracellular	constitutive, basal level of catalase activity. Inhibition of extracellular catalase activity by 3-amino-1,2,4-triazole or KCN leads to a striking inactivation of secreted cysteine cathepsins	Homo sapiens	-	-
1.11.1.6	peroxisome	main localization	Homo sapiens	5777	-

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.11.1.6	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.11.1.6	THP-1 cell	-	Homo sapiens	-

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Release 2023.1 (January 2023)