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Literature summary extracted from

  • Ko, K.M.; Lee, W.; Yu, J.R.; Ahnn, J.
    PYP-1, inorganic pyrophosphatase, is required for larval development and intestinal function in C. elegans (2007), FEBS Lett., 581, 5445-5453.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.6.1.1 gene pyp-1, DNA and amino acid sequence determination and analysis, genomic organization, expression in transformed adult progeny worms using the promoterless GFP vector, pPD95.75 vector Caenorhabditis elegans

Protein Variants

EC Number Protein Variants Comment Organism
3.6.1.1 additional information isolation of pyp-1 deletion mutant, a constructed null mutant of pyp-1 reveals a developmental arrest at early larval stages and exhibits gross defects in intestinal morphology and function, phenotype, overview Caenorhabditis elegans

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.6.1.1 cytoplasm
-
 Caenorhabditis elegans 5737
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.1.1 diphosphate + H2O Caenorhabditis elegans diphosphate hydrolysis provides a thermodynamic driving force for important biosynthetic reactions, PYP-1 is required for larval development and intestinal function, overview 2 phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.1 Caenorhabditis elegans Q18680 Bristol strain N2, gene C47E12.4 or pyp-1
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.6.1.1 coelomocyte
-
 Caenorhabditis elegans
-
3.6.1.1 intestine PYP-1 is required for larval development and intestinal function, overview Caenorhabditis elegans
-
3.6.1.1 larva PYP-1 is required for larval development and intestinal function, overview Caenorhabditis elegans
-
3.6.1.1 additional information expression can be detected from larval stages through adult stages Caenorhabditis elegans
-
3.6.1.1 nervous system nerve cords and sensory neurons Caenorhabditis elegans
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.6.1.1 1570
-
 recombinant enzyme Caenorhabditis elegans

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.1 diphosphate + H2O
-
 Caenorhabditis elegans 2 phosphate
-
 ?
3.6.1.1 diphosphate + H2O diphosphate hydrolysis provides a thermodynamic driving force for important biosynthetic reactions, PYP-1 is required for larval development and intestinal function, overview Caenorhabditis elegans 2 phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.6.1.1 inorganic pyrophosphatase
-
 Caenorhabditis elegans
3.6.1.1 PPase
-
 Caenorhabditis elegans
3.6.1.1 PYP-1
-
 Caenorhabditis elegans