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Literature summary extracted from

  • Kim, H.L.; Choi, Y.K.; Kim, d.o..H.; Park, S.O.; Han, J.; Park, Y.S.
    Tetrahydropteridine deficiency impairs mitochondrial function in Dictyostelium discoideum Ax2 (2007), FEBS Lett., 581, 5430-5434.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.1.1.153 additional information construction of a mutant disrupted in the gene encoding sepiapterin reductase, the SR mutant produces about 3% of tetrahydropteridines compared to the wild-type and shows several functional defects related to mitochondria and oxidative stress, as retarded growth, poor spore viability, impaired mitochondrial function, and increased susceptibility to oxidative stress induced by hydroxylamine or cumene-hydroperoxide, overview. The physiological defects are almost completely rescued by extrachromosomal expression of the endogenous enzyme Dictyostelium discoideum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.153 6-pyruvoyl-5,6,7,8-tetrahydropterin + NADPH Dictyostelium discoideum
-
 tetrahydrobiopterin + NADP+
-
 r
1.1.1.153 additional information Dictyostelium discoideum tetrahydropteridines in Dictyostelium are associated with mitochondrial function, probably via direct protection against oxidative stress, tetrahydropteridine deficiency impairs mitochondrial function in Dictyostelium discoideum Ax2 ?
-
 ?
1.1.1.153 sepiapterin + NADPH + H+ Dictyostelium discoideum
-
 7,8-dihydrobiopterin + NADP+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.153 Dictyostelium discoideum
-
 axenic strain Ax2
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.153 6-pyruvoyl-5,6,7,8-tetrahydropterin + NADPH
-
 Dictyostelium discoideum tetrahydrobiopterin + NADP+
-
 r
1.1.1.153 additional information tetrahydropteridines in Dictyostelium are associated with mitochondrial function, probably via direct protection against oxidative stress, tetrahydropteridine deficiency impairs mitochondrial function in Dictyostelium discoideum Ax2 Dictyostelium discoideum ?
-
 ?
1.1.1.153 additional information the enzyme catalyzes the final step in the tetrahydrobiopterin biosynthesis Dictyostelium discoideum ?
-
 ?
1.1.1.153 sepiapterin + NADPH + H+
-
 Dictyostelium discoideum 7,8-dihydrobiopterin + NADP+
-
 r