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Literature summary extracted from

  • Zhao, C.; Slevin, J.T.; Whiteheart, S.W.
    Cellular functions of NSF: not just SNAPs and SNAREs (2007), FEBS Lett., 581, 2140-2149.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
3.6.4.6 E329Q hydrolysis mutant Saccharomyces cerevisiae
3.6.4.6 E350Q hydrolysis mutant Saccharomyces cerevisiae
3.6.4.6 G282E mutant protein has no ATPase activity Mammalia
3.6.4.6 K266A ATP-binding mutant Saccharomyces cerevisiae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.6.4.6 Golgi membrane NSF requires a peripheral membrane protein to bind Golgi membranes Drosophila melanogaster 139
-
3.6.4.6 Golgi membrane NSF requires a peripheral membrane protein to bind Golgi membranes Mammalia 139
-
3.6.4.6 Golgi membrane NSF requires a peripheral membrane protein to bind Golgi membranes Rattus norvegicus 139
-
3.6.4.6 Golgi membrane NSF requires a peripheral membrane protein to bind Golgi membranes Saccharomyces cerevisiae 139
-
3.6.4.6 synaptosome
-
 Rattus norvegicus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.6.4.6 Mg2+
-
 Drosophila melanogaster
3.6.4.6 Mg2+
-
 Mammalia
3.6.4.6 Mg2+
-
 Rattus norvegicus
3.6.4.6 Mg2+
-
 Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.4.6 ATP + H2O Drosophila melanogaster
-
 ADP + phosphate
-
 ir
3.6.4.6 ATP + H2O Mammalia
-
 ADP + phosphate
-
 ir
3.6.4.6 ATP + H2O Rattus norvegicus
-
 ADP + phosphate
-
 ir
3.6.4.6 ATP + H2O Saccharomyces cerevisiae
-
 ADP + phosphate
-
 ir

Organism

EC Number Organism UniProt Comment Textmining
3.6.4.6 Drosophila melanogaster
-
-
-
3.6.4.6 Drosophila melanogaster P46461
-
-
3.6.4.6 Mammalia
-
-
-
3.6.4.6 Rattus norvegicus
-
-
-
3.6.4.6 Saccharomyces cerevisiae
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.6.4.6 phosphoprotein
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.6.4.6 brain
-
 Rattus norvegicus
-
3.6.4.6 central nervous system
-
 Drosophila melanogaster
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.4.6 ATP + H2O
-
 Drosophila melanogaster ADP + phosphate
-
 ir
3.6.4.6 ATP + H2O
-
 Mammalia ADP + phosphate
-
 ir
3.6.4.6 ATP + H2O
-
 Rattus norvegicus ADP + phosphate
-
 ir
3.6.4.6 ATP + H2O
-
 Saccharomyces cerevisiae ADP + phosphate
-
 ir

Subunits

EC Number Subunits Comment Organism
3.6.4.6 homohexamer
-
 Drosophila melanogaster
3.6.4.6 homohexamer
-
 Mammalia
3.6.4.6 homohexamer
-
 Rattus norvegicus
3.6.4.6 homohexamer
-
 Saccharomyces cerevisiae

Synonyms

EC Number Synonyms Comment Organism
3.6.4.6 dNSF1 isoform 1 Drosophila melanogaster
3.6.4.6 dNSF1 isoform 2 Drosophila melanogaster
3.6.4.6 N-ethylmaleimide sensitive factor
-
 Drosophila melanogaster
3.6.4.6 N-ethylmaleimide sensitive factor
-
 Mammalia
3.6.4.6 N-ethylmaleimide sensitive factor
-
 Rattus norvegicus
3.6.4.6 N-ethylmaleimide sensitive factor
-
 Saccharomyces cerevisiae
3.6.4.6 NSF
-
 Drosophila melanogaster
3.6.4.6 NSF
-
 Mammalia
3.6.4.6 NSF
-
 Rattus norvegicus
3.6.4.6 NSF
-
 Saccharomyces cerevisiae