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Literature summary extracted from

  • Kang, K.A.; Lee, K.H.; Park, J.W.; Lee, N.H.; Na, H.K.; Surh, Y.J.; You, H.J.; Chung, M.H.; Hyun, J.W.
    Triphlorethol-A induces heme oxygenase-1 via activation of ERK and NF-E2 related factor 2 transcription factor (2007), FEBS Lett., 581, 2000-2008.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.14.18 additional information triphlorethol-A, i.e. 2-[2-(3,5-dihydroxyphenoxy)-3,5-dihydroxyphenoxy]benzene-1,3,5-triol, a phlorotannin isolated from Ecklonia cava, induces heme oxygenase-1 via activation of ERK and NF-E2 related factor 2 transcription factor, triphlorethol-A increases nuclear translocation, ARE, binding, and transcriptional activity of Nrf2, transcription factor Nrf2 regulates antioxidant response element, ARE, of phase 2 detoxifying and antioxidant enzymes, requirement for ERK activation in the induction of HO-1 expression by triphlorethol-A because an ERK inhibitor significantly reduces HO-1 protein expression in response to triphlorethol-A, overview Cricetulus griseus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.14.18 zinc protoporphyrin ZnPP Cricetulus griseus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.14.18 Mg2+
-
 Cricetulus griseus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.18 heme + AH2 + O2 Cricetulus griseus induction of HO-1 via the ERK-Nrf2-ARE signaling pathway is involved in protecting cells from oxidative stress, overview biliverdin + Fe2+ + CO + A + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.18 Cricetulus griseus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.18 lung fibroblast
-
 Cricetulus griseus
-
1.14.14.18 V-79-4 cell
-
 Cricetulus griseus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.18 heme + AH2 + O2
-
 Cricetulus griseus biliverdin + Fe2+ + CO + A + H2O
-
 ?
1.14.14.18 heme + AH2 + O2 induction of HO-1 via the ERK-Nrf2-ARE signaling pathway is involved in protecting cells from oxidative stress, overview Cricetulus griseus biliverdin + Fe2+ + CO + A + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.18 heme oxygenase-1
-
 Cricetulus griseus
1.14.14.18 HO-1
-
 Cricetulus griseus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.14.14.18 37
-
 assay at Cricetulus griseus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.14.14.18 7.4
-
 assay at Cricetulus griseus