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Literature summary extracted from

  • Linster, C.L.; Van Schaftingen, E.
    Vitamin C. Biosynthesis, recycling and degradation in mammals (2007), FEBS J., 274, 1-22.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.19 sorbinil
-
 Homo sapiens
1.1.1.19 sorbinil
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.19 0.33
-
 D-glucuronate
-
 Homo sapiens
1.1.1.19 0.69
-
 D-glucuronolactone
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.19 endoplasmic reticulum membrane
-
 Homo sapiens 5789
-
1.1.1.19 endoplasmic reticulum membrane
-
 Rattus norvegicus 5789
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.19 D-glucuronate + NADPH Homo sapiens
-
 L-gulonate + NADP+
-
 r
1.1.1.19 D-glucuronate + NADPH Rattus norvegicus a step in ascorbic acid biosynthesis, overview L-gulonate + NADP+
-
 r
1.1.1.19 D-glucuronolactone + NADPH Homo sapiens
-
 L-gulonolactone + NADP+
-
 r
1.1.1.19 D-glucuronolactone + NADPH Rattus norvegicus
-
 L-gulonolactone + NADP+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.19 Homo sapiens
-
-
-
1.1.1.19 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.19 liver
-
 Homo sapiens
-
1.1.1.19 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.19 D-glucuronate + NADPH
-
 Homo sapiens L-gulonate + NADP+
-
 r
1.1.1.19 D-glucuronate + NADPH
-
 Rattus norvegicus L-gulonate + NADP+
-
 r
1.1.1.19 D-glucuronate + NADPH a step in ascorbic acid biosynthesis, overview Rattus norvegicus L-gulonate + NADP+
-
 r
1.1.1.19 D-glucuronolactone + NADPH
-
 Homo sapiens L-gulonolactone + NADP+
-
 r
1.1.1.19 D-glucuronolactone + NADPH
-
 Rattus norvegicus L-gulonolactone + NADP+
-
 r

Subunits

EC Number Subunits Comment Organism
1.1.1.19 monomer
-
 Homo sapiens
1.1.1.19 monomer
-
 Rattus norvegicus

Synonyms

EC Number Synonyms Comment Organism
1.1.1.19 AKR1A1
-
 Homo sapiens
1.1.1.19 AKR1A1
-
 Rattus norvegicus
1.1.1.19 aldehyde reductase
-
 Homo sapiens
1.1.1.19 aldehyde reductase
-
 Rattus norvegicus
1.1.1.19 More the enzyme belongs to the aldo-keto reductase superfamily Homo sapiens
1.1.1.19 More the enzyme belongs to the aldo-keto reductase superfamily Rattus norvegicus
1.1.1.19 TPN l-hexonate dehydrogenase
-
 Homo sapiens
1.1.1.19 TPN l-hexonate dehydrogenase
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.19 NADP+ dependent on Homo sapiens
1.1.1.19 NADP+ dependent on Rattus norvegicus
1.1.1.19 NADPH dependent on Homo sapiens
1.1.1.19 NADPH dependent on Rattus norvegicus