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Literature summary extracted from

  • Kumar, P.; Sundar, S.; Singh, N.
    Degradation of pteridine reductase 1 (PTR1) enzyme during growth phase in the protozoan parasite Leishmania donovani (2007), Exp. Parasitol., 116, 182-189.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.5.1.33 promastigote form of Leishmania donovani transfected with GFP and GFP-PTR1 chimera Leishmania donovani

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.5.1.33 cytoplasm
-
 Leishmania donovani 5737
-
1.5.1.33 flagellum in stationary phase promastigotes Leishmania donovani
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.5.1.33 57000
-
 x * 57000, SDS-PAGE, GFP-fusion protein Leishmania donovani

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.5.1.33 2 biopterin + 3 NADPH + 3 H+ Leishmania donovani essential enzyme of pterin and folate metabolism dihydrobiopterin + tetrahydrobiopterin + 3 NADP+
-
 ?
1.5.1.33 folate + NADPH + H+ Leishmania donovani essential enzyme of pterin and folate metabolism 7,8-dihydrofolate + tetrahydrofolate + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.33 Leishmania donovani Q6QDB5 clinical isolate, enzyme is degraded in the stationary phase of growth at the time when the parasites are undergoing metacyclogenesis
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.1.33 2 biopterin + 3 NADPH + 3 H+ essential enzyme of pterin and folate metabolism Leishmania donovani dihydrobiopterin + tetrahydrobiopterin + 3 NADP+
-
 ?
1.5.1.33 folate + NADPH + H+ essential enzyme of pterin and folate metabolism Leishmania donovani 7,8-dihydrofolate + tetrahydrofolate + NADP+
-
 ?

Subunits

EC Number Subunits Comment Organism
1.5.1.33 More x * 57000, SDS-PAGE, GFP-fusion protein Leishmania donovani
1.5.1.33 tetramer
-
 Leishmania donovani

Synonyms

EC Number Synonyms Comment Organism
1.5.1.33 pteridine reductase 1 broad-spectrum enzyme of pterin and folate metabolism Leishmania donovani
1.5.1.33 PTR1
-
 Leishmania donovani

Cofactor

EC Number Cofactor Comment Organism Structure
1.5.1.33 NADPH
-
 Leishmania donovani