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Literature summary extracted from

  • Hammond, L.E.; Albright, C.D.; He, L.; Rusyn, I.; Watkins, S.M.; Doughman, S.D.; Lemasters, J.J.; Coleman, R.A.
    Increased oxidative stress is associated with balanced increases in hepatocyte apoptosis and proliferation in glycerol-3-phosphate acyltransferase-1 deficient mice (2007), Exp. Mol. Pathol., 82, 210-219.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.15 Insulin Gpat1 is upregulated by insulin Mus musculus
2.3.1.15 SREBP-1 Gpat1 is upregulated by SREBP-1 Mus musculus

Application

EC Number Application Comment Organism
2.3.1.15 medicine Gpat1-/- mouse may be a useful model in which to study novel relationships between hepatic mitochondrial dysfunction, oxidative stress, apoptosis, proliferation, and cancer susceptibility Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.15 AMP-activated protein kinase AMP-activated protein kinase reciprocally regulates GPAT1 Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.15 mitochondrial outer membrane
-
 Mus musculus 5741
-
2.3.1.15 mitochondrion
-
 Mus musculus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.15 acyl-CoA + sn-glycerol 3-phosphate Mus musculus
-
 CoA + 1-acyl-sn-glycerol 3-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.15 Mus musculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.15 liver mitochondria are prepared Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.15 liver
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.15 acyl-CoA + sn-glycerol 3-phosphate
-
 Mus musculus CoA + 1-acyl-sn-glycerol 3-phosphate
-
 ?
2.3.1.15 fatty acyl-CoA + glycerol-3-phosphate long-chain fatty acyl-CoA Mus musculus CoA + lysophosphatidic acid
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.15 glycerol-3-phosphate acyltransferase-1
-
 Mus musculus