Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Adamek, A.; Jung, S.; Dienesch, C.; Laser, M.; Ertl, G.; Bauersachs, J.; Frantz, S.
    Role of 5-lipoxygenase in myocardial ischemia-reperfusion injury in mice (2007), Eur. J. Pharmacol., 571, 51-54.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.13.11.34 additional information construction of enzyme-deficient knockout mice, 5-LOX deficient and wild-type mice show no significant difference in infarct size after 30 min of coronary artery ligation and 24 h of reperfusion, but neutrophil infiltration as well as tumor necrosis factor expression are increased in 5-lipoxygenase-deficient mice, overview Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.34 (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate Mus musculus
-
leukotriene A4 + H2O is unstable and metabolized to leukotriene B4 ?
1.13.11.34 arachidonic acid + O2 Mus musculus
-
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
?
1.13.11.34 additional information Mus musculus inhibition of 5-lipoxygenase does not affect cardiac ischemia-reperfusion injury but the post-ischemic inflammatory response, overview ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.34 Mus musculus P48999
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.34 heart
-
Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.34 (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
Mus musculus leukotriene A4 + H2O
-
?
1.13.11.34 (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
Mus musculus leukotriene A4 + H2O is unstable and metabolized to leukotriene B4 ?
1.13.11.34 arachidonic acid + O2
-
Mus musculus (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
?
1.13.11.34 additional information inhibition of 5-lipoxygenase does not affect cardiac ischemia-reperfusion injury but the post-ischemic inflammatory response, overview Mus musculus ?
-
?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.34 5-lipoxygenase
-
Mus musculus